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Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target.
Wang H, Tang S, Wu Q, He Y, Zhu W, Xie X, Qin Z, Wang X, Zhou S, Yao S, Xu X, Guo C, Tong X, Han S, Chou YH, Wang Y, Wong KK, Yang CG, Chen L, Hu L, Ji H. Wang H, et al. Among authors: chen l. Natl Sci Rev. 2024 Nov 7;11(12):nwae392. doi: 10.1093/nsr/nwae392. eCollection 2024 Dec. Natl Sci Rev. 2024. PMID: 39687207 Free PMC article.
Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation.
Fang Z, Han X, Chen Y, Tong X, Xue Y, Yao S, Tang S, Pan Y, Sun Y, Wang X, Jin Y, Chen H, Hu L, Hui L, Li L, Chen L, Ji H. Fang Z, et al. Among authors: chen l, chen h, chen y. Signal Transduct Target Ther. 2023 Jan 11;8(1):16. doi: 10.1038/s41392-022-01227-0. Signal Transduct Target Ther. 2023. PMID: 36627278 Free PMC article.
Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer.
Tong X, Patel AS, Kim E, Li H, Chen Y, Li S, Liu S, Dilly J, Kapner KS, Zhang N, Xue Y, Hover L, Mukhopadhyay S, Sherman F, Myndzar K, Sahu P, Gao Y, Li F, Li F, Fang Z, Jin Y, Gao J, Shi M, Sinha S, Chen L, Chen Y, Kheoh T, Yang W, Yanai I, Moreira AL, Velcheti V, Neel BG, Hu L, Christensen JG, Olson P, Gao D, Zhang MQ, Aguirre AJ, Wong KK, Ji H. Tong X, et al. Among authors: chen l, chen y. Cancer Cell. 2024 Mar 11;42(3):413-428.e7. doi: 10.1016/j.ccell.2024.01.012. Epub 2024 Feb 22. Cancer Cell. 2024. PMID: 38402609 Free article.
TAZ inhibits SCLC metastasis through GALNT18-mediated O-glycosylation.
Zhang Z, Xu Z, Qian X, Chen Y, Li D, Qin Z, Chen L, Zhang Y, Jin Y, Ji H. Zhang Z, et al. Among authors: chen l, chen y. J Genet Genomics. 2024 Nov;51(11):1314-1317. doi: 10.1016/j.jgg.2024.09.001. Epub 2024 Sep 10. J Genet Genomics. 2024. PMID: 39260682 No abstract available.
Integrated characterization of hepatobiliary tumor organoids provides a potential landscape of pharmacogenomic interactions.
Zhu Y, Tang S, Yuan Q, Fu J, He J, Liu Z, Zhao X, Li Y, Zhao Y, Zhang Y, Zhang X, Zhang Y, Zhu Y, Wang W, Zheng B, Wu R, Wu T, Yang S, Qiu X, Shen S, Hu J, Chen L, Wang Y, Wang H, Gao D, Chen L. Zhu Y, et al. Among authors: chen l. Cell Rep Med. 2024 Feb 20;5(2):101375. doi: 10.1016/j.xcrm.2023.101375. Epub 2024 Jan 25. Cell Rep Med. 2024. PMID: 38278146 Free PMC article.
Novel protein kinase inhibitor TT-00420 inhibits gallbladder cancer by inhibiting JNK/JUN-mediated signaling pathway.
Miao H, Geng Y, Li Y, Tang S, Feng F, Li W, Li Y, Liu L, Zhang R, Qiu S, Wu Y, Wang Z, Wang Z, Shao Z, Liu K, Zou L, Yang M, Zhao Y, Chen C, Li Z, Zhang D, Peng P, Qiang X, Wu F, He Y, Chen L, Xiang D, Jiang X, Li M, Liu Y, Liu Y. Miao H, et al. Among authors: chen l, chen c. Cell Oncol (Dordr). 2022 Aug;45(4):689-708. doi: 10.1007/s13402-022-00692-7. Epub 2022 Jul 23. Cell Oncol (Dordr). 2022. PMID: 35870050
PRMT5-mediated FUBP1 methylation accelerates prostate cancer progression.
Yan W, Liu X, Qiu X, Zhang X, Chen J, Xiao K, Wu P, Peng C, Hu X, Wang Z, Qin J, Sun L, Chen L, Wu D, Huang S, Yin L, Li Z. Yan W, et al. Among authors: chen j, chen l. J Clin Invest. 2024 Aug 15;134(18):e175023. doi: 10.1172/JCI175023. J Clin Invest. 2024. PMID: 39146021 Free PMC article.
Foundation models in molecular biology.
Si Y, Zou J, Gao Y, Chuai G, Liu Q, Chen L. Si Y, et al. Among authors: chen l. Biophys Rep. 2024 Jun 30;10(3):135-151. doi: 10.52601/bpr.2024.240006. Biophys Rep. 2024. PMID: 39027316 Free PMC article.
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