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Page 1
Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design.
Hryczanek RP, Hackett AS, Rowland P, Chung CW, Convery MA, Holmes DS, Hutchinson JP, Kitchen S, Korczynska J, Law RP, Lea JD, Liddle J, Lonsdale R, Neu M, Nickels L, Phillipou A, Rowedder JE, Schneck JL, Scott-Stevens P, Sheehan H, Tayler CL, Temponeras I, Tinworth CP, Walker AL, Wojno-Picon J, Young RJ, Lindsay DM, Stratikos E. Hryczanek RP, et al. Among authors: tinworth cp. ACS Med Chem Lett. 2024 Nov 6;15(12):2107-2114. doi: 10.1021/acsmedchemlett.4c00401. eCollection 2024 Dec 12. ACS Med Chem Lett. 2024. PMID: 39691536 Free PMC article.
Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs).
Zhang Q, Kounde CS, Mondal M, Greenfield JL, Baker JR, Kotelnikov S, Ignatov M, Tinworth CP, Zhang L, Conole D, De Vita E, Kozakov D, McCluskey A, Harling JD, Fuchter MJ, Tate EW. Zhang Q, et al. Among authors: tinworth cp. Chem Commun (Camb). 2022 Sep 29;58(78):10933-10936. doi: 10.1039/d2cc03092f. Chem Commun (Camb). 2022. PMID: 36065962 Free PMC article.
Computational Mapping of Dirhodium(II) Catalysts.
Green AI, Tinworth CP, Warriner S, Nelson A, Fey N. Green AI, et al. Among authors: tinworth cp. Chemistry. 2021 Feb 1;27(7):2402-2409. doi: 10.1002/chem.202003801. Epub 2021 Jan 12. Chemistry. 2021. PMID: 32964545 Free PMC article.
Structural Insights into PROTAC-Mediated Degradation of Bcl-xL.
Chung CW, Dai H, Fernandez E, Tinworth CP, Churcher I, Cryan J, Denyer J, Harling JD, Konopacka A, Queisser MA, Tame CJ, Watt G, Jiang F, Qian D, Benowitz AB. Chung CW, et al. Among authors: tinworth cp. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323. doi: 10.1021/acschembio.0c00266. Epub 2020 Aug 13. ACS Chem Biol. 2020. PMID: 32697072
Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation.
Liddle J, Hutchinson JP, Kitchen S, Rowland P, Neu M, Cecconie T, Holmes DS, Jones E, Korczynska J, Koumantou D, Lea JD, Nickels L, Pemberton M, Phillipou A, Schneck JL, Sheehan H, Tinworth CP, Uings I, Wojno-Picon J, Young RJ, Stratikos E. Liddle J, et al. Among authors: tinworth cp. J Med Chem. 2020 Mar 26;63(6):3348-3358. doi: 10.1021/acs.jmedchem.9b02123. Epub 2020 Mar 9. J Med Chem. 2020. PMID: 32109056