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Dextromethorphan inhibits collagen and collagen-like cargo secretion to ameliorate lung fibrosis.
Khan MM, Galea G, Jung J, Zukowska J, Lauer D, Tuechler N, Halavatyi A, Tischer C, Haberkant P, Stein F, Jung F, Landry JJM, Khan AM, Oorschot V, Becher I, Neumann B, Muley T, Winter H, Duerr J, Mall MA, Grassi A, de la Cueva E, Benes V, Gote-Schniering J, Savitski M, Pepperkok R. Khan MM, et al. Among authors: mall ma. Sci Transl Med. 2024 Dec 18;16(778):eadj3087. doi: 10.1126/scitranslmed.adj3087. Epub 2024 Dec 18. Sci Transl Med. 2024. PMID: 39693409
The ENaC-overexpressing mouse as a model of cystic fibrosis lung disease.
Zhou Z, Duerr J, Johannesson B, Schubert SC, Treis D, Harm M, Graeber SY, Dalpke A, Schultz C, Mall MA. Zhou Z, et al. Among authors: mall ma. J Cyst Fibros. 2011 Jun;10 Suppl 2:S172-82. doi: 10.1016/S1569-1993(11)60021-0. J Cyst Fibros. 2011. PMID: 21658636 Free article. Review.
SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation.
Anagnostopoulou P, Riederer B, Duerr J, Michel S, Binia A, Agrawal R, Liu X, Kalitzki K, Xiao F, Chen M, Schatterny J, Hartmann D, Thum T, Kabesch M, Soleimani M, Seidler U, Mall MA. Anagnostopoulou P, et al. Among authors: mall ma. J Clin Invest. 2012 Oct;122(10):3629-34. doi: 10.1172/JCI60429. Epub 2012 Sep 4. J Clin Invest. 2012. PMID: 22945630 Free PMC article.
Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.
Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA. Gehrig S, et al. Among authors: mall ma. Am J Respir Crit Care Med. 2014 May 1;189(9):1082-92. doi: 10.1164/rccm.201311-1932OC. Am J Respir Crit Care Med. 2014. PMID: 24678594
Lung arginase expression and activity is increased in cystic fibrosis mouse models.
Jaecklin T, Duerr J, Huang H, Rafii M, Bear CE, Ratjen F, Pencharz P, Kavanagh BP, Mall MA, Grasemann H. Jaecklin T, et al. Among authors: mall ma. J Appl Physiol (1985). 2014 Aug 1;117(3):284-8. doi: 10.1152/japplphysiol.00167.2014. Epub 2014 Jun 12. J Appl Physiol (1985). 2014. PMID: 24925982 Free article.
Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease.
Fritzsching B, Zhou-Suckow Z, Trojanek JB, Schubert SC, Schatterny J, Hirtz S, Agrawal R, Muley T, Kahn N, Sticht C, Gunkel N, Welte T, Randell SH, Länger F, Schnabel P, Herth FJ, Mall MA. Fritzsching B, et al. Among authors: mall ma. Am J Respir Crit Care Med. 2015 Apr 15;191(8):902-13. doi: 10.1164/rccm.201409-1610OC. Am J Respir Crit Care Med. 2015. PMID: 25607238 Free PMC article.
302 results