Wegerski CJ - Search Results

1

Absorption, single-dose and steady-state metabolism, excretion, and pharmacokinetics of adagrasib, a KRAS^G12C inhibitor.

Rahbaek L, Cilliers C, Wegerski CJ, Nguyen N, Otten J, Hargis L, Marx MA, Christensen JG, Tran JQ. Rahbaek L, et al. Among authors: wegerski cj. Cancer Chemother Pharmacol. 2024 Dec 19;95(1):7. doi: 10.1007/s00280-024-04728-7. Cancer Chemother Pharmacol. 2024. PMID: 39699634

2

1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties.

Nilewski C, Michels TD, Packard GK, Xiang AX, Sprengeler PA, Eam B, Fish S, Thompson PA, Wegerski CJ, Nevarez A, Clarine J, Sperry S, Ernst JT, Reich SH. Nilewski C, et al. Among authors: wegerski cj. Bioorg Med Chem Lett. 2021 Sep 1;47:128111. doi: 10.1016/j.bmcl.2021.128111. Epub 2021 Aug 2. Bioorg Med Chem Lett. 2021. PMID: 34353608

3

Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.

Thompson PA, Eam B, Young NP, Fish S, Chen J, Barrera M, Howard H, Sung E, Parra A, Staunton J, Chiang GG, Gerson-Gurwitz A, Wegerski CJ, Nevarez A, Clarine J, Sperry S, Xiang A, Nilewski C, Packard GK, Michels T, Tran C, Sprengeler PA, Ernst JT, Reich SH, Webster KR. Thompson PA, et al. Among authors: wegerski cj. Mol Cancer Ther. 2021 Jan;20(1):26-36. doi: 10.1158/1535-7163.MCT-19-0973. Epub 2020 Oct 9. Mol Cancer Ther. 2021. PMID: 33037136

4

Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors.

Nilewski C, Michels TD, Xiang AX, Packard GK, Sprengeler PA, Eam B, Fish S, Thompson PA, Wegerski CJ, Ernst JT, Reich SH. Nilewski C, et al. Among authors: wegerski cj. Org Lett. 2020 Aug 21;22(16):6257-6261. doi: 10.1021/acs.orglett.0c01944. Epub 2020 Jul 30. Org Lett. 2020. PMID: 32806219

5

Disposition and metabolism of 2',2'"-Dithiobisbenzanilide in rodents following intravenous and oral administration and dermal application.

Garner CE, Wegerski CJ, Doyle-Eisele M, McDonald JD, Sanders JM, Moeller BC, Waidyanatha S. Garner CE, et al. Among authors: wegerski cj. Toxicol Rep. 2020 Jul 23;7:883-892. doi: 10.1016/j.toxrep.2020.07.006. eCollection 2020. Toxicol Rep. 2020. PMID: 32760656 Free PMC article.

6

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.

Ernst JT, Thompson PA, Nilewski C, Sprengeler PA, Sperry S, Packard G, Michels T, Xiang A, Tran C, Wegerski CJ, Eam B, Young NP, Fish S, Chen J, Howard H, Staunton J, Molter J, Clarine J, Nevarez A, Chiang GG, Appleman JR, Webster KR, Reich SH. Ernst JT, et al. Among authors: wegerski cj. J Med Chem. 2020 Jun 11;63(11):5879-5955. doi: 10.1021/acs.jmedchem.0c00182. Epub 2020 May 29. J Med Chem. 2020. PMID: 32470302

7

Metabolism and disposition of 2-hydroxy-4-methoxybenzophenone, a sunscreen ingredient, in Harlan Sprague Dawley rats and B6C3F1/N mice; a species and route comparison.

Mutlu E, Garner CE, Wegerski CJ, McDonald JD, McIntyre BS, Doyle-Eisele M, Waidyanatha S. Mutlu E, et al. Among authors: wegerski cj. Xenobiotica. 2020 Jun;50(6):689-704. doi: 10.1080/00498254.2019.1680906. Epub 2019 Oct 31. Xenobiotica. 2020. PMID: 31613170 Free PMC article.

8

Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.

Shipkowski KA, Sanders JM, McDonald JD, Garner CE, Doyle-Eisele M, Wegerski CJ, Waidyanatha S. Shipkowski KA, et al. Among authors: wegerski cj. Toxicol Appl Pharmacol. 2019 Sep 1;378:114592. doi: 10.1016/j.taap.2019.05.011. Epub 2019 May 14. Toxicol Appl Pharmacol. 2019. PMID: 31100288 Free PMC article.

9

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

Reich SH, Sprengeler PA, Chiang GG, Appleman JR, Chen J, Clarine J, Eam B, Ernst JT, Han Q, Goel VK, Han EZR, Huang V, Hung INJ, Jemison A, Jessen KA, Molter J, Murphy D, Neal M, Parker GS, Shaghafi M, Sperry S, Staunton J, Stumpf CR, Thompson PA, Tran C, Webber SE, Wegerski CJ, Zheng H, Webster KR. Reich SH, et al. Among authors: wegerski cj. J Med Chem. 2018 Apr 26;61(8):3516-3540. doi: 10.1021/acs.jmedchem.7b01795. Epub 2018 Mar 29. J Med Chem. 2018. PMID: 29526098

10

Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure.

Waidyanatha S, Ryan K, Sanders JM, McDonald JD, Wegerski CJ, Doyle-Eisle M, Garner CE. Waidyanatha S, et al. Among authors: wegerski cj. Toxicol Appl Pharmacol. 2018 Jan 15;339:151-160. doi: 10.1016/j.taap.2017.12.008. Epub 2017 Dec 15. Toxicol Appl Pharmacol. 2018. PMID: 29248465

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