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Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis.
Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Takahashi A, Matsuda J, Minami S, Sakai S, Yonishi H, Maeda S, Matsui S, Kawai H, Matsui I, Yamamuro T, Edahiro R, Takashima S, Takasawa A, Okada Y, Yoshimori T, Ballabio A, Isaka Y. Nakamura J, et al. Among authors: isaka y. JCI Insight. 2024 Dec 19:e184451. doi: 10.1172/jci.insight.184451. Online ahead of print. JCI Insight. 2024. PMID: 39699959 Free article.
TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.
Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y. Nakamura J, et al. Among authors: isaka y. JCI Insight. 2023 Feb 22;8(4):e162498. doi: 10.1172/jci.insight.162498. JCI Insight. 2023. PMID: 36649084 Free PMC article.
Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules.
Takahashi A, Takabatake Y, Kimura T, Maejima I, Namba T, Yamamoto T, Matsuda J, Minami S, Kaimori JY, Matsui I, Matsusaka T, Niimura F, Yoshimori T, Isaka Y. Takahashi A, et al. Among authors: isaka y. Diabetes. 2017 May;66(5):1359-1372. doi: 10.2337/db16-0397. Epub 2017 Feb 28. Diabetes. 2017. PMID: 28246295
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori JY, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y. Matsuda J, et al. Among authors: isaka y. Autophagy. 2020 Oct;16(10):1889-1904. doi: 10.1080/15548627.2020.1712107. Epub 2020 Jan 16. Autophagy. 2020. PMID: 31944172 Free PMC article.
LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
Nakamura S, Shigeyama S, Minami S, Shima T, Akayama S, Matsuda T, Esposito A, Napolitano G, Kuma A, Namba-Hamano T, Nakamura J, Yamamoto K, Sasai M, Tokumura A, Miyamoto M, Oe Y, Fujita T, Terawaki S, Takahashi A, Hamasaki M, Yamamoto M, Okada Y, Komatsu M, Nagai T, Takabatake Y, Xu H, Isaka Y, Ballabio A, Yoshimori T. Nakamura S, et al. Among authors: isaka y. Nat Cell Biol. 2020 Oct;22(10):1252-1263. doi: 10.1038/s41556-020-00583-9. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989250
Pathological mechanisms of kidney disease in ageing.
Yamamoto T, Isaka Y. Yamamoto T, et al. Among authors: isaka y. Nat Rev Nephrol. 2024 Sep;20(9):603-615. doi: 10.1038/s41581-024-00868-4. Epub 2024 Jul 18. Nat Rev Nephrol. 2024. PMID: 39025993 Review.
Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules.
Matsui S, Yamamoto T, Takabatake Y, Takahashi A, Namba-Hamano T, Matsuda J, Minami S, Sakai S, Yonishi H, Nakamura J, Maeda S, Matsumoto A, Matsui I, Yanagita M, Isaka Y. Matsui S, et al. Among authors: isaka y. Autophagy. 2024 Oct 14:1-15. doi: 10.1080/15548627.2024.2410621. Online ahead of print. Autophagy. 2024. PMID: 39385699
Autophagy guards against cisplatin-induced acute kidney injury.
Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y, Rakugi H. Takahashi A, et al. Among authors: isaka y. Am J Pathol. 2012 Feb;180(2):517-25. doi: 10.1016/j.ajpath.2011.11.001. Am J Pathol. 2012. PMID: 22265049
559 results