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Page 1
Age-related TFEB downregulation in proximal tubules causes systemic metabolic disorders and occasional apolipoprotein A4-related amyloidosis.
Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Takahashi A, Matsuda J, Minami S, Sakai S, Yonishi H, Maeda S, Matsui S, Kawai H, Matsui I, Yamamuro T, Edahiro R, Takashima S, Takasawa A, Okada Y, Yoshimori T, Ballabio A, Isaka Y. Nakamura J, et al. Among authors: sakai s. JCI Insight. 2024 Dec 19:e184451. doi: 10.1172/jci.insight.184451. Online ahead of print. JCI Insight. 2024. PMID: 39699959 Free article.
TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.
Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y. Nakamura J, et al. Among authors: sakai s. JCI Insight. 2023 Feb 22;8(4):e162498. doi: 10.1172/jci.insight.162498. JCI Insight. 2023. PMID: 36649084 Free PMC article.
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori JY, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y. Matsuda J, et al. Among authors: sakai s. Autophagy. 2020 Oct;16(10):1889-1904. doi: 10.1080/15548627.2020.1712107. Epub 2020 Jan 16. Autophagy. 2020. PMID: 31944172 Free PMC article.
Empagliflozin protects the kidney by reducing toxic ALB (albumin) exposure and preventing autophagic stagnation in proximal tubules.
Matsui S, Yamamoto T, Takabatake Y, Takahashi A, Namba-Hamano T, Matsuda J, Minami S, Sakai S, Yonishi H, Nakamura J, Maeda S, Matsumoto A, Matsui I, Yanagita M, Isaka Y. Matsui S, et al. Among authors: sakai s. Autophagy. 2024 Oct 14:1-15. doi: 10.1080/15548627.2024.2410621. Online ahead of print. Autophagy. 2024. PMID: 39385699
Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes.
Sakai S, Yamamoto T, Takabatake Y, Takahashi A, Namba-Hamano T, Minami S, Fujimura R, Yonishi H, Matsuda J, Hesaka A, Matsui I, Matsusaka T, Niimura F, Yanagita M, Isaka Y. Sakai S, et al. J Am Soc Nephrol. 2019 Jun;30(6):929-945. doi: 10.1681/ASN.2018100983. Epub 2019 Apr 30. J Am Soc Nephrol. 2019. PMID: 31040190 Free PMC article.
Autophagy protects kidney from phosphate-induced mitochondrial injury.
Fujimura R, Yamamoto T, Takabatake Y, Takahashi A, Namba-Hamano T, Minami S, Sakai S, Matsuda J, Hesaka A, Yonishi H, Nakamura J, Matsui I, Matsusaka T, Niimura F, Yanagita M, Isaka Y. Fujimura R, et al. Among authors: sakai s. Biochem Biophys Res Commun. 2020 Apr 9;524(3):636-642. doi: 10.1016/j.bbrc.2020.01.137. Epub 2020 Feb 3. Biochem Biophys Res Commun. 2020. PMID: 32029271
Eicosapentaenoic acid attenuates renal lipotoxicity by restoring autophagic flux.
Yamamoto T, Takabatake Y, Minami S, Sakai S, Fujimura R, Takahashi A, Namba-Hamano T, Matsuda J, Kimura T, Matsui I, Kaimori JY, Takeda H, Takahashi M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Isaka Y. Yamamoto T, et al. Among authors: sakai s. Autophagy. 2021 Jul;17(7):1700-1713. doi: 10.1080/15548627.2020.1782034. Epub 2020 Jun 28. Autophagy. 2021. PMID: 32546086 Free PMC article.
Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis.
Yamamoto-Imoto H, Minami S, Shioda T, Yamashita Y, Sakai S, Maeda S, Yamamoto T, Oki S, Takashima M, Yamamuro T, Yanagawa K, Edahiro R, Iwatani M, So M, Tokumura A, Abe T, Imamura R, Nonomura N, Okada Y, Ayer DE, Ogawa H, Hara E, Takabatake Y, Isaka Y, Nakamura S, Yoshimori T. Yamamoto-Imoto H, et al. Among authors: sakai s. Cell Rep. 2022 Mar 1;38(9):110444. doi: 10.1016/j.celrep.2022.110444. Cell Rep. 2022. PMID: 35235784 Free article.
MondoA and AKI and AKI-to-CKD Transition.
Maeda S, Sakai S, Takabatake Y, Yamamoto T, Minami S, Nakamura J, Namba-Hamano T, Takahashi A, Matsuda J, Yonishi H, Matsui S, Imai A, Edahiro R, Yamamoto-Imoto H, Matsui I, Takashima S, Imamura R, Nonomura N, Yanagita M, Okada Y, Ballabio A, Nakamura S, Yoshimori T, Isaka Y. Maeda S, et al. Among authors: sakai s. J Am Soc Nephrol. 2024 May 31;35(9):1164-82. doi: 10.1681/ASN.0000000000000414. Online ahead of print. J Am Soc Nephrol. 2024. PMID: 38819935
2,727 results