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Microsatellite instability and high tumor mutational burden detected by next generation sequencing are concordant with loss of mismatch repair proteins by immunohistochemistry.
Yang RK, Alvarez H, Lucas AS, Roy-Chowdhuri S, Rashid A, Chen H, Ballester LY, Sweeney K, Routbort MJ, Patel KP, Luthra R, Medeiros LJ, Toruner GA. Yang RK, et al. Among authors: luthra r. Cancer Genet. 2025 Jan;290-291:44-50. doi: 10.1016/j.cancergen.2024.12.002. Epub 2024 Dec 15. Cancer Genet. 2025. PMID: 39700818
Somatic deletions of the polyA tract in the 3' untranslated region of epidermal growth factor receptor are common in microsatellite instability-high endometrial and colorectal carcinomas.
Deqin M, Chen Z, Nero C, Patel KP, Daoud EM, Cheng H, Djordjevic B, Broaddus RR, Medeiros LJ, Rashid A, Luthra R. Deqin M, et al. Among authors: luthra r. Arch Pathol Lab Med. 2012 May;136(5):510-6. doi: 10.5858/arpa.2010-0638-OA. Arch Pathol Lab Med. 2012. PMID: 22540299 Free PMC article.
Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases.
Ok CY, Patel KP, Garcia-Manero G, Routbort MJ, Fu B, Tang G, Goswami M, Singh R, Kanagal-Shamanna R, Pierce SA, Young KH, Kantarjian HM, Medeiros LJ, Luthra R, Wang SA. Ok CY, et al. Among authors: luthra r. Leuk Res. 2015 Mar;39(3):348-54. doi: 10.1016/j.leukres.2014.12.006. Epub 2014 Dec 20. Leuk Res. 2015. PMID: 25573287 Free PMC article.
Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors.
Goswami RS, Patel KP, Singh RR, Meric-Bernstam F, Kopetz ES, Subbiah V, Alvarez RH, Davies MA, Jabbar KJ, Roy-Chowdhuri S, Lazar AJ, Medeiros LJ, Broaddus RR, Luthra R, Routbort MJ. Goswami RS, et al. Among authors: luthra r. Clin Cancer Res. 2015 Jun 1;21(11):2644-51. doi: 10.1158/1078-0432.CCR-14-2391. Epub 2015 Feb 18. Clin Cancer Res. 2015. PMID: 25695693 Free PMC article.
Factors affecting the success of next-generation sequencing in cytology specimens.
Roy-Chowdhuri S, Goswami RS, Chen H, Patel KP, Routbort MJ, Singh RR, Broaddus RR, Barkoh BA, Manekia J, Yao H, Medeiros LJ, Staerkel G, Luthra R, Stewart J. Roy-Chowdhuri S, et al. Among authors: luthra r. Cancer Cytopathol. 2015 Nov;123(11):659-68. doi: 10.1002/cncy.21597. Epub 2015 Jul 31. Cancer Cytopathol. 2015. PMID: 26230354 Free article.
435 results