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Physiological shedding and C-terminal proteolytic processing of TMEM106B.
Held S, Erck C, Kemppainen S, Bleibaum F, Giridhar NJ, Feederle R, Krenner C, Juopperi SP, Calliari A, Mentrup T, Schröder B, Dickson DW, Rauramaa T, Petrucelli L, Prudencio M, Hiltunen M, Lüningschrör P, Capell A, Damme M. Held S, et al. Among authors: rauramaa t. Cell Rep. 2024 Dec 21;44(1):115107. doi: 10.1016/j.celrep.2024.115107. Online ahead of print. Cell Rep. 2024. PMID: 39709600 Free article.
Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome.
Luikku AJ, Nerg O, Koivisto AM, Hänninen T, Junkkari A, Kemppainen S, Juopperi SP, Sinisalo R, Pesola A, Soininen H, Hiltunen M, Leinonen V, Rauramaa T, Martiskainen H. Luikku AJ, et al. Among authors: rauramaa t. J Neuropathol Exp Neurol. 2024 Nov 1;83(11):967-978. doi: 10.1093/jnen/nlae083. J Neuropathol Exp Neurol. 2024. PMID: 39101555 Free PMC article.
MECP2 Increases the Pro-Inflammatory Response of Microglial Cells and Phosphorylation at Serine 423 Regulates Neuronal Gene Expression upon Neuroinflammation.
Wittrahm R, Takalo M, Marttinen M, Kuulasmaa T, Mäkinen P, Kemppainen S, Martiskainen H, Rauramaa T, Pike I, Leinonen V, Natunen T, Haapasalo A, Hiltunen M. Wittrahm R, et al. Among authors: rauramaa t. Cells. 2021 Apr 9;10(4):860. doi: 10.3390/cells10040860. Cells. 2021. PMID: 33918872 Free PMC article.
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
Kurkinen KM, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, Sarajärvi T, Gabbouj S, Kurki M, Paananen J, Koivisto AM, Rauramaa T, Leinonen V, Tanila H, Soininen H, Lucas FR, Haapasalo A, Hiltunen M. Kurkinen KM, et al. Among authors: rauramaa t. J Cell Sci. 2016 Jun 1;129(11):2224-38. doi: 10.1242/jcs.185215. Epub 2016 Apr 15. J Cell Sci. 2016. PMID: 27084579
Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.
Natunen T, Martiskainen H, Marttinen M, Gabbouj S, Koivisto H, Kemppainen S, Kaipainen S, Takalo M, Svobodová H, Leppänen L, Kemiläinen B, Ryhänen S, Kuulasmaa T, Rahunen E, Juutinen S, Mäkinen P, Miettinen P, Rauramaa T, Pihlajamäki J, Haapasalo A, Leinonen V, Tanila H, Hiltunen M. Natunen T, et al. Among authors: rauramaa t. Mol Neurodegener. 2020 Nov 10;15(1):66. doi: 10.1186/s13024-020-00415-2. Mol Neurodegener. 2020. PMID: 33168021 Free PMC article.
Early Alzheimer's disease pathology in human cortex involves transient cell states.
Gazestani V, Kamath T, Nadaf NM, Dougalis A, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Pelkonen A, Gomez-Budia M, Välimäki NN, Rauramaa T, Therrien M, Koivisto AM, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh SE, Hiltunen M, Nehme R, Malm T, Stevens B, Leinonen V, Macosko EZ. Gazestani V, et al. Among authors: rauramaa t. Cell. 2023 Sep 28;186(20):4438-4453.e23. doi: 10.1016/j.cell.2023.08.005. Cell. 2023. PMID: 37774681 Free PMC article.
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KMA, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M. Natunen T, et al. Among authors: rauramaa t. Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10. Neurobiol Dis. 2016. PMID: 26563932
81 results