Rofo F - Search Results

1

A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro.

Petersen I, Morrison JI, Petrovic A, Babic N, Metzendorf NG, Godec A, de la Rosa A, Rofo F, Bondza S, Buijs J, Ranjbarian F, Hofer A, Sehlin D, Hultqvist G. Petersen I, et al. Among authors: rofo f. Sci Rep. 2024 Dec 23;14(1):30613. doi: 10.1038/s41598-024-83627-6. Sci Rep. 2024. PMID: 39715817 Free PMC article.

2

Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates.

Petersen I, Ali MI, Petrovic A, Ytterberg AJ, Staxäng K, Hodik M, Rofo F, Bondza S, Hultqvist G. Petersen I, et al. Among authors: rofo f. MAbs. 2023 Jan-Dec;15(1):2256668. doi: 10.1080/19420862.2023.2256668. Epub 2023 Sep 22. MAbs. 2023. PMID: 37737124 Free PMC article.

3

Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways.

Morrison JI, Petrovic A, Metzendorf NG, Rofo F, Yilmaz CU, Stenler S, Laudon H, Hultqvist G. Morrison JI, et al. Among authors: rofo f. Mol Pharm. 2023 Mar 6;20(3):1564-1576. doi: 10.1021/acs.molpharmaceut.2c00768. Epub 2023 Feb 21. Mol Pharm. 2023. PMID: 36808999 Free PMC article.

4

A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses.

Morrison JI, Metzendorf NG, Rofo F, Petrovic A, Hultqvist G. Morrison JI, et al. Among authors: rofo f. J Neurochem. 2023 May;165(3):413-425. doi: 10.1111/jnc.15768. Epub 2023 Feb 10. J Neurochem. 2023. PMID: 36681883 Free article.

5

Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3.

de la Rosa A, Metzendorf NG, Morrison JI, Faresjö R, Rofo F, Petrovic A, O'Callaghan P, Syvänen S, Hultqvist G. de la Rosa A, et al. Among authors: rofo f. Sci Rep. 2022 Dec 12;12(1):21479. doi: 10.1038/s41598-022-25965-x. Sci Rep. 2022. PMID: 36509864 Free PMC article.

6

Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer's disease.

Rofo F, Metzendorf NG, Saubi C, Suominen L, Godec A, Sehlin D, Syvänen S, Hultqvist G. Rofo F, et al. Alzheimers Res Ther. 2022 Dec 5;14(1):180. doi: 10.1186/s13195-022-01132-2. Alzheimers Res Ther. 2022. PMID: 36471433 Free PMC article.

7

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice.

Rofo F, Meier SR, Metzendorf NG, Morrison JI, Petrovic A, Syvänen S, Sehlin D, Hultqvist G. Rofo F, et al. Neurotherapeutics. 2022 Sep;19(5):1588-1602. doi: 10.1007/s13311-022-01283-y. Epub 2022 Aug 8. Neurotherapeutics. 2022. PMID: 35939261 Free PMC article.

8

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta.

Rofo F, Buijs J, Falk R, Honek K, Lannfelt L, Lilja AM, Metzendorf NG, Gustavsson T, Sehlin D, Söderberg L, Hultqvist G. Rofo F, et al. Transl Neurodegener. 2021 Sep 28;10(1):38. doi: 10.1186/s40035-021-00258-x. Transl Neurodegener. 2021. PMID: 34579778 Free PMC article.

9

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide.

Rofo F, Sandbaumhüter FA, Chourlia A, Metzendorf NG, Morrison JI, Syvänen S, Andrén PE, Jansson ET, Hultqvist G. Rofo F, et al. ACS Chem Neurosci. 2021 Jul 7;12(13):2529-2541. doi: 10.1021/acschemneuro.1c00303. Epub 2021 Jun 25. ACS Chem Neurosci. 2021. PMID: 34170117 Free PMC article.

10

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain.

Rofo F, Ugur Yilmaz C, Metzendorf N, Gustavsson T, Beretta C, Erlandsson A, Sehlin D, Syvänen S, Nilsson P, Hultqvist G. Rofo F, et al. Theranostics. 2021 Jan 1;11(2):789-804. doi: 10.7150/thno.50263. eCollection 2021. Theranostics. 2021. PMID: 33391505 Free PMC article.

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