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Technologies for Targeted RNA Degradation and Induced RNA Decay.
Mikutis S, Bernardes GJL. Mikutis S, et al. Among authors: bernardes gjl. Chem Rev. 2024 Dec 11;124(23):13301-13330. doi: 10.1021/acs.chemrev.4c00472. Epub 2024 Nov 5. Chem Rev. 2024. PMID: 39499674 Free PMC article. Review.
Site-Specific Quadruple-Functionalised Antibodies.
Journeaux T, Geeson MB, Murray TV, Papworth MA, Gothard M, Kettle JG, Vasco AV, Bernardes GJL. Journeaux T, et al. Among authors: bernardes gjl. Angew Chem Int Ed Engl. 2024 Oct 18:e202417620. doi: 10.1002/anie.202417620. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 39423140
Designed endocytosis-inducing proteins degrade targets and amplify signals.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Tang C, Wang R, Schlichthaerle T, Zhang JZ, Wang Y, Goreshnik I, Chiu CW, Chazin-Gray A, Chan S, Gerben S, Murray A, Wang S, O'Neill J, Yi L, Yeh R, Misquith A, Wolf A, Tomasovic LM, Piraner DI, Duran Gonzalez MJ, Bennett NR, Venkatesh P, Ahlrichs M, Dobbins C, Yang W, Wang X, Sahtoe DD, Vafeados D, Mout R, Shivaei S, Cao L, Carter L, Stewart L, Spangler JB, Roybal KT, Greisen PJ, Li X, Bernardes GJL, Bertozzi CR, Baker D. Huang B, et al. Among authors: bernardes gjl. Nature. 2024 Sep 25. doi: 10.1038/s41586-024-07948-2. Online ahead of print. Nature. 2024. PMID: 39322662
Proximity-driven site-specific cyclization of phage-displayed peptides.
Brown L, Vidal AV, Dias AL, Rodrigues T, Sigurdardottir A, Journeaux T, O'Brien S, Murray TV, Ravn P, Papworth M, Bernardes GJL. Brown L, et al. Among authors: bernardes gjl. Nat Commun. 2024 Aug 24;15(1):7308. doi: 10.1038/s41467-024-51610-4. Nat Commun. 2024. PMID: 39181880 Free PMC article.
Small Molecule RNA Degraders.
Bonet-Aleta J, Maehara T, Craig BA, Bernardes GJL. Bonet-Aleta J, et al. Among authors: bernardes gjl. Angew Chem Int Ed Engl. 2024 Nov 18;63(47):e202412925. doi: 10.1002/anie.202412925. Epub 2024 Oct 17. Angew Chem Int Ed Engl. 2024. PMID: 39162084 Review.
Homogeneous multi-payload antibody-drug conjugates.
Journeaux T, Bernardes GJL. Journeaux T, et al. Among authors: bernardes gjl. Nat Chem. 2024 Jun;16(6):854-870. doi: 10.1038/s41557-024-01507-y. Epub 2024 May 17. Nat Chem. 2024. PMID: 38760431 Review.
186 results