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Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction.
Chartier CA, Woods VA, Xu Y, van Vlimmeren AE, Johns AC, Jovanovic M, McDermott AE, Keedy DA, Shah NH. Chartier CA, et al. Among authors: keedy da. bioRxiv [Preprint]. 2024 Nov 11:2024.07.16.603632. doi: 10.1101/2024.07.16.603632. bioRxiv. 2024. Update in: Protein Sci. 2025 Jan;34(1):e70016. doi: 10.1002/pro.70016 PMID: 39071364 Free PMC article. Updated. Preprint.
Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.
Perdikari A, Woods VA, Ebrahim A, Lawler K, Bounds R, Singh NI, Mehlman TS, Riley BT, Sharma S, Morris JW, Keogh JM, Henning E, Smith M, Farooqi IS, Keedy DA. Perdikari A, et al. Among authors: keedy da. bioRxiv [Preprint]. 2024 Aug 7:2024.08.05.603709. doi: 10.1101/2024.08.05.603709. bioRxiv. 2024. PMID: 39149290 Free PMC article. Preprint.
High-resolution double vision of the allosteric phosphatase PTP1B.
Sharma S, Skaist Mehlman T, Sagabala RS, Boivin B, Keedy DA. Sharma S, et al. Among authors: keedy da. Acta Crystallogr F Struct Biol Commun. 2024 Jan 1;80(Pt 1):1-12. doi: 10.1107/S2053230X23010749. Epub 2024 Jan 1. Acta Crystallogr F Struct Biol Commun. 2024. PMID: 38133579 Free PMC article.
39 results