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The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain.
van Vlimmeren AE, Voleti R, Chartier CA, Jiang Z, Karandur D, Humphries PA, Lo WL, Shah NH. van Vlimmeren AE, et al. bioRxiv [Preprint]. 2024 Apr 9:2023.07.10.548257. doi: 10.1101/2023.07.10.548257. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Jul 23;121(30):e2407159121. doi: 10.1073/pnas.2407159121 PMID: 37502916 Free PMC article. Updated. Preprint.
An atlas of substrate specificities for the human serine/threonine kinome.
Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin TY, Liberatore K, Cizin DM, Cohen BM, Vasan N, Ma Y, Krismer K, Robles JT, van de Kooij B, van Vlimmeren AE, Andrée-Busch N, Käufer NF, Dorovkov MV, Ryazanov AG, Takagi Y, Kastenhuber ER, Goncalves MD, Hopkins BD, Elemento O, Taatjes DJ, Maucuer A, Yamashita A, Degterev A, Uduman M, Lu J, Landry SD, Zhang B, Cossentino I, Linding R, Blenis J, Hornbeck PV, Turk BE, Yaffe MB, Cantley LC. Johnson JL, et al. Among authors: van vlimmeren ae. Nature. 2023 Jan;613(7945):759-766. doi: 10.1038/s41586-022-05575-3. Epub 2023 Jan 11. Nature. 2023. PMID: 36631611 Free PMC article.