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AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition.
Kang H, Valerio M, Feng J, Gu L, Hoang DH, Blackmon A, Sharkas S, Pathak K, Jossart J, Li Z, Zhang H, Zhang B, Pirrotte P, Perry JJP, Hickey RJ, Malkas L, Marcucci G, Nguyen LXT. Kang H, et al. Among authors: malkas l. Exp Hematol Oncol. 2024 Dec 28;13(1):123. doi: 10.1186/s40164-024-00586-4. Exp Hematol Oncol. 2024. PMID: 39732733 Free PMC article.
Small molecule targeting of transcription-replication conflict for selective chemotherapy.
Gu L, Li M, Li CM, Haratipour P, Lingeman R, Jossart J, Gutova M, Flores L, Hyde C, Kenjić N, Li H, Chung V, Li H, Lomenick B, Von Hoff DD, Synold TW, Aboody KS, Liu Y, Horne D, Hickey RJ, Perry JJP, Malkas LH. Gu L, et al. Among authors: malkas lh. Cell Chem Biol. 2023 Oct 19;30(10):1235-1247.e6. doi: 10.1016/j.chembiol.2023.07.001. Epub 2023 Aug 1. Cell Chem Biol. 2023. PMID: 37531956 Free PMC article.
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination.
Wang YC, Kelso AA, Karamafrooz A, Chen YH, Chen WK, Cheng CT, Qi Y, Gu L, Malkas L, Taglialatela A, Kung HJ, Moldovan GL, Ciccia A, Stark JM, Ann DK. Wang YC, et al. Among authors: malkas l. Cell Rep. 2023 Apr 25;42(4):112296. doi: 10.1016/j.celrep.2023.112296. Epub 2023 Mar 23. Cell Rep. 2023. PMID: 36961817 Free PMC article.
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination.
Wang YC, Kelso AA, Karamafrooz A, Chen YH, Chen WK, Cheng CT, Qi Y, Gu L, Malkas L, Kung HJ, Moldovan GL, Ciccia A, Stark JM, Ann DK. Wang YC, et al. Among authors: malkas l. bioRxiv [Preprint]. 2023 Feb 3:2023.01.31.526362. doi: 10.1101/2023.01.31.526362. bioRxiv. 2023. Update in: Cell Rep. 2023 Apr 25;42(4):112296. doi: 10.1016/j.celrep.2023.112296 PMID: 36778247 Free PMC article. Updated. Preprint.
Novel Peptide Therapeutic Approaches for Cancer Treatment.
Li CM, Haratipour P, Lingeman RG, Perry JJP, Gu L, Hickey RJ, Malkas LH. Li CM, et al. Among authors: malkas lh. Cells. 2021 Oct 27;10(11):2908. doi: 10.3390/cells10112908. Cells. 2021. PMID: 34831131 Free PMC article. Review.
87 results