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Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and In Vivo Exposure.
da Silva FF, Paz JD, Rambo RS, Gonçalves GA, Muniz MN, de Matos Czeczot A, Perelló MA, Berger A, González LC, Duarte LS, da Silva AB, Ferreira CAS, de Oliveira SD, Moura S, Bizarro CV, Basso LA, Machado P. da Silva FF, et al. Among authors: basso la. J Med Chem. 2024 Dec 26;67(24):21781-21794. doi: 10.1021/acs.jmedchem.4c01302. Epub 2024 Dec 4. J Med Chem. 2024. PMID: 39630172 Free PMC article.
Losartan and enalapril maleate differently influence SARS-CoV-2-infected vero cells.
Majolo JH, Gonçalves JIB, Souza RP, González LC, Sperotto N, Silveira MD, Oliveira SD, Bizarro CV, Machado P, Basso LA, Souza APD, Oliveira JR, Ferreira CAS. Majolo JH, et al. Among authors: basso la. Sci Rep. 2024 Oct 22;14(1):24801. doi: 10.1038/s41598-024-76657-7. Sci Rep. 2024. PMID: 39433817 Free PMC article.
Production Process Optimization of Recombinant Erwinia carotovoral-Asparaginase II in Escherichia coli Fed-Batch Cultures and Analysis of Antileukemic Potential.
de Andrade BC, Renard G, Gennari A, Artico LL, Júnior JRT, Kuhn D, Salles PPZ, Volken de Souza CF, Roth G, Chies JM, Yunes JA, Basso LA. de Andrade BC, et al. Among authors: basso la. ACS Omega. 2024 Aug 3;9(32):34951-34963. doi: 10.1021/acsomega.4c04711. eCollection 2024 Aug 13. ACS Omega. 2024. PMID: 39157126 Free PMC article.
Crystal structure of dihydroneopterin aldolase from Mycobacterium tuberculosis associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, in vitro toxicity and antitubercular activity.
Czeczot AM, Muniz MN, Perelló MA, Silva ÉED, Timmers LFSM, Berger A, Gonzalez LC, Arraché Gonçalves G, Moura S, Machado P, Bizarro CV, Basso LA. Czeczot AM, et al. Among authors: basso la. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2388207. doi: 10.1080/14756366.2024.2388207. Epub 2024 Aug 14. J Enzyme Inhib Med Chem. 2024. PMID: 39140692 Free PMC article.
Identification of antimycobacterial 8-hydroxyquinoline derivatives as in vitro enzymatic inhibitors of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase.
Joaquim AR, Lopes MS, Fortes IS, de Bem Gentz C, de Matos Czeczot A, Perelló MA, Roth CD, Vainstein MH, Basso LA, Bizarro CV, Machado P, de Andrade SF. Joaquim AR, et al. Among authors: basso la. Bioorg Chem. 2024 Oct;151:107705. doi: 10.1016/j.bioorg.2024.107705. Epub 2024 Aug 10. Bioorg Chem. 2024. PMID: 39137600
Effect of metformin in hypothalamic astrocytes from an immunocompromised mice model.
Bobermin LD, da Costa DS, de Moraes ADM, da Silva VF, de Oliveira GT, Sesterheim P, Tramontina AC, Basso LA, Leipnitz G, Quincozes-Santos A, Gonçalves CA. Bobermin LD, et al. Among authors: basso la. Biochimie. 2024 Aug;223:196-205. doi: 10.1016/j.biochi.2024.04.005. Epub 2024 Apr 18. Biochimie. 2024. PMID: 38642825
199 results