Zhu L - Search Results

1

Tamsulosin ameliorates bone loss by inhibiting the release of Cl^- through wedging into an allosteric site of TMEM16A.

Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y. Li S, et al. Among authors: zhu l. Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2407493121. doi: 10.1073/pnas.2407493121. Epub 2024 Dec 31. Proc Natl Acad Sci U S A. 2025. PMID: 39739807

2

Binding Free Energy Calculation Based on the Fragment Molecular Orbital Method and Its Application in Designing Novel SHP-2 Allosteric Inhibitors.

Yuan Z, Chen X, Fan S, Chang L, Chu L, Zhang Y, Wang J, Li S, Xie J, Hu J, Miao R, Zhu L, Zhao Z, Li H, Li S. Yuan Z, et al. Among authors: zhu l. Int J Mol Sci. 2024 Jan 4;25(1):671. doi: 10.3390/ijms25010671. Int J Mol Sci. 2024. PMID: 38203841 Free PMC article.

3

Discovery of a novel SHP2 allosteric inhibitor using virtual screening, FMO calculation, and molecular dynamic simulation.

Yuan Z, Zhang M, Chang L, Chen X, Ruan S, Shi S, Zhang Y, Zhu L, Li H, Li S. Yuan Z, et al. Among authors: zhu l. J Mol Model. 2024 Apr 13;30(5):131. doi: 10.1007/s00894-024-05935-y. J Mol Model. 2024. PMID: 38613643

4

Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity.

Li S, Luan G, Ren X, Song W, Xu L, Xu M, Zhu J, Dong D, Diao Y, Liu X, Zhu L, Wang R, Zhao Z, Xu Y, Li H. Li S, et al. Among authors: zhu j, zhu l. Sci Rep. 2015 Oct 7;5:14836. doi: 10.1038/srep14836. Sci Rep. 2015. PMID: 26443076 Free PMC article.

5

Design, Synthesis, and Structure-Activity Relationship Study of Potent MAPK11 Inhibitors.

Gong M, Tu M, Sun H, Li L, Zhu L, Li H, Zhao Z, Li S. Gong M, et al. Among authors: zhu l. Molecules. 2021 Dec 29;27(1):203. doi: 10.3390/molecules27010203. Molecules. 2021. PMID: 35011435 Free PMC article.

6

Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors.

Dou D, Wang J, Qiao Y, Wumaier G, Sha W, Li W, Mei W, Yang T, Zhang C, He H, Wang C, Chu L, Sun B, Su R, Ma X, Gong M, Xie L, Jiang W, Diao Y, Zhu L, Zhao Z, Chen Z, Xu Y, Li S, Li H. Dou D, et al. Among authors: zhu l. Eur J Med Chem. 2022 Dec 15;244:114856. doi: 10.1016/j.ejmech.2022.114856. Epub 2022 Oct 17. Eur J Med Chem. 2022. PMID: 36279692

7

Efficacy of WWQ-131, a highly selective JAK2 inhibitor, in mouse models of myeloproliferative neoplasms.

Ge H, Wang C, Tian C, Diao Y, Wang W, Ma X, Zhang J, Li H, Zhao Z, Zhu L. Ge H, et al. Among authors: zhu l. Biomed Pharmacother. 2022 Dec;156:113884. doi: 10.1016/j.biopha.2022.113884. Epub 2022 Oct 25. Biomed Pharmacother. 2022. PMID: 36306591 Free article.

8

Design, synthesis and structure-activity relationship of malonic acid non-nucleoside derivatives as potent CD73 inhibitors.

Shi C, Dai J, Chang L, Xu W, Huang C, Zhao Z, Li H, Zhu L, Xu Y. Shi C, et al. Among authors: zhu l. Bioorg Med Chem Lett. 2024 Nov 1;112:129946. doi: 10.1016/j.bmcl.2024.129946. Epub 2024 Sep 1. Bioorg Med Chem Lett. 2024. PMID: 39226996

9

Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase.

Zhu J, Han L, Diao Y, Ren X, Xu M, Xu L, Li S, Li Q, Dong D, Huang J, Liu X, Zhao Z, Wang R, Zhu L, Xu Y, Qian X, Li H. Zhu J, et al. Among authors: zhu l. J Med Chem. 2015 Feb 12;58(3):1123-39. doi: 10.1021/jm501127s. Epub 2015 Jan 26. J Med Chem. 2015. PMID: 25580811

10

Macrocyclization of linear molecules by deep learning to facilitate macrocyclic drug candidates discovery.

Diao Y, Liu D, Ge H, Zhang R, Jiang K, Bao R, Zhu X, Bi H, Liao W, Chen Z, Zhang K, Wang R, Zhu L, Zhao Z, Hu Q, Li H. Diao Y, et al. Among authors: zhu x, zhu l. Nat Commun. 2023 Jul 28;14(1):4552. doi: 10.1038/s41467-023-40219-8. Nat Commun. 2023. PMID: 37507402 Free PMC article.

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