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Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.
Hsu C, Jones SA, Cohen CJ, Zheng Z, Kerstann K, Zhou J, Robbins PF, Peng PD, Shen X, Gomes TJ, Dunbar CE, Munroe DJ, Stewart C, Cornetta K, Wangsa D, Ried T, Rosenberg SA, Morgan RA. Hsu C, et al. Among authors: morgan ra. Blood. 2007 Jun 15;109(12):5168-77. doi: 10.1182/blood-2006-06-029173. Epub 2007 Mar 12. Blood. 2007. PMID: 17353346 Free PMC article.
T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.
Parkhurst MR, Yang JC, Langan RC, Dudley ME, Nathan DA, Feldman SA, Davis JL, Morgan RA, Merino MJ, Sherry RM, Hughes MS, Kammula US, Phan GQ, Lim RM, Wank SA, Restifo NP, Robbins PF, Laurencot CM, Rosenberg SA. Parkhurst MR, et al. Among authors: morgan ra. Mol Ther. 2011 Mar;19(3):620-6. doi: 10.1038/mt.2010.272. Epub 2010 Dec 14. Mol Ther. 2011. PMID: 21157437 Free PMC article. Clinical Trial.
Collapse of the tumor stroma is triggered by IL-12 induction of Fas.
Kerkar SP, Leonardi AJ, van Panhuys N, Zhang L, Yu Z, Crompton JG, Pan JH, Palmer DC, Morgan RA, Rosenberg SA, Restifo NP. Kerkar SP, et al. Among authors: morgan ra. Mol Ther. 2013 Jul;21(7):1369-77. doi: 10.1038/mt.2013.58. Epub 2013 Apr 9. Mol Ther. 2013. PMID: 23568260 Free PMC article.
352 results