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FBP1 controls liver cancer evolution from senescent MASH hepatocytes.
Gu L, Zhu Y, Nandi SP, Lee M, Watari K, Bareng B, Ohira M, Liu Y, Sakane S, Carlessi R, Sauceda C, Dhar D, Ganguly S, Hosseini M, Teneche MG, Adams PD, Gonzalez DJ, Kisseleva T; Liver Cancer Collaborative; Tirnitz-Parker JEE, Simon MC, Alexandrov LB, Karin M. Gu L, et al. Among authors: tirnitz parker jee. Nature. 2025 Jan 1. doi: 10.1038/s41586-024-08317-9. Online ahead of print. Nature. 2025. PMID: 39743585
Patient-derived organoid models to decode liver pathophysiology.
Dwyer BJ, Tirnitz-Parker JEE. Dwyer BJ, et al. Among authors: tirnitz parker jee. Trends Endocrinol Metab. 2024 Aug 26:S1043-2760(24)00200-5. doi: 10.1016/j.tem.2024.07.019. Online ahead of print. Trends Endocrinol Metab. 2024. PMID: 39191607 Review.
SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition.
Lai X, Lui SKL, Lam HY, Adachi Y, Sim WJ, Vasilevski N, Armstrong NJ, Bridgeman SC, Main NM, Tan TZ, Tirnitz-Parker JEE, Thiery JP, Ebi H, Kumar AP, Eichhorn PJA. Lai X, et al. Among authors: tirnitz parker jee. NPJ Precis Oncol. 2023 Dec 15;7(1):136. doi: 10.1038/s41698-023-00486-6. NPJ Precis Oncol. 2023. PMID: 38102334 Free PMC article.
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
Boslem E, Reibe S, Carlessi R, Smeuninx B, Tegegne S, Egan CL, McLennan E, Terry LV, Nobis M, Mu A, Nowell C, Horadagoda N, Henstridge DC, Mellett NA, Timpson P, Jones M, Denisenko E, Forrest ARR, Tirnitz-Parker JEE, Meikle PJ, Rose-John S, Karin M, Febbraio MA. Boslem E, et al. Among authors: tirnitz parker jee. Sci Adv. 2023 Sep 15;9(37):eadh0831. doi: 10.1126/sciadv.adh0831. Epub 2023 Sep 13. Sci Adv. 2023. PMID: 37703359 Free PMC article.
Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential.
Carlessi R, Denisenko E, Boslem E, Köhn-Gaone J, Main N, Abu Bakar NDB, Shirolkar GD, Jones M, Beasley AB, Poppe D, Dwyer BJ, Jackaman C, Tjiam MC, Lister R, Karin M, Fallowfield JA, Kendall TJ, Forbes SJ, Gray ES, Olynyk JK, Yeoh G, Forrest ARR, Ramm GA, Febbraio MA, Tirnitz-Parker JEE. Carlessi R, et al. Among authors: tirnitz parker jee. Cell Genom. 2023 Apr 13;3(5):100301. doi: 10.1016/j.xgen.2023.100301. eCollection 2023 May 10. Cell Genom. 2023. PMID: 37228755 Free PMC article.
Cachexia causes time-dependent activation of the inflammasome in the liver.
das Neves RX, Yamashita AS, Riccardi DMR, Köhn-Gaone J, Camargo RG, Neto NI, Caetano D, Gomes SP, Santos FH, Lima JDCC, Batista ML Jr, Rosa-Neto JC, Martins De Alcântara PS, Maximiano LF, Otoch JP, Trinchieri G, Tirnitz-Parker JEE, Seelaender M. das Neves RX, et al. Among authors: tirnitz parker jee. J Cachexia Sarcopenia Muscle. 2023 Aug;14(4):1621-1630. doi: 10.1002/jcsm.13236. Epub 2023 May 12. J Cachexia Sarcopenia Muscle. 2023. PMID: 37177862 Free PMC article.
TWEAK/Fn14 Signalling Regulates the Tissue Microenvironment in Chronic Pancreatitis.
Abu Bakar NDB, Carlessi R, Gogoi-Tiwari J, Köhn-Gaone J, Williams V, Falasca M, Olynyk JK, Ramm GA, Tirnitz-Parker JEE. Abu Bakar NDB, et al. Among authors: tirnitz parker jee. Cancers (Basel). 2023 Mar 16;15(6):1807. doi: 10.3390/cancers15061807. Cancers (Basel). 2023. PMID: 36980694 Free PMC article.
Characterization of the humanized FRG mouse model and development of an AAV-LK03 variant with improved liver lobular biodistribution.
Cabanes-Creus M, Navarro RG, Liao SHY, Scott S, Carlessi R, Roca-Pinilla R, Knight M, Baltazar G, Zhu E, Jones M, Denisenko E, Forrest ARR, Alexander IE, Tirnitz-Parker JEE, Lisowski L. Cabanes-Creus M, et al. Among authors: tirnitz parker jee. Mol Ther Methods Clin Dev. 2023 Jan 2;28:220-237. doi: 10.1016/j.omtm.2022.12.014. eCollection 2023 Mar 9. Mol Ther Methods Clin Dev. 2023. PMID: 36700121 Free PMC article.
44 results