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Development of PRC1 Inhibitors Employing Fragment-Based Approach and NMR-Guided Optimization.
J Med Chem. 2025 Jan 23;68(2):1382-1396. doi: 10.1021/acs.jmedchem.4c01955. Epub 2025 Jan 2.
J Med Chem. 2025.
PMID: 39746899
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Shukla S, Ying W, Gray F, Yao Y, Simes ML, Zhao Q, Miao H, Cho HJ, González-Alonso P, Winkler A, Lund G, Purohit T, Kim E, Zhang X, Ray JM, He S, Nikolaidis C, Ndoj J, Wang J, Jaremko Ł, Jaremko M, Ryan RJH, Guzman ML, Grembecka J, Cierpicki T.
Shukla S, et al. Among authors: simes ml.
Nat Chem Biol. 2021 Jul;17(7):784-793. doi: 10.1038/s41589-021-00815-5. Epub 2021 Jun 21.
Nat Chem Biol. 2021.
PMID: 34155404
Free PMC article.
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Development of potent dimeric inhibitors of GAS41 YEATS domain.
Listunov D, Linhares BM, Kim E, Winkler A, Simes ML, Weaver S, Cho HJ, Rizo A, Zolov S, Keshamouni VG, Grembecka J, Cierpicki T.
Listunov D, et al. Among authors: simes ml.
Cell Chem Biol. 2021 Dec 16;28(12):1716-1727.e6. doi: 10.1016/j.chembiol.2021.06.010. Epub 2021 Jul 21.
Cell Chem Biol. 2021.
PMID: 34289376
Free PMC article.
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