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Page 1
Generic residue numbering of the GAIN domain of adhesion GPCRs.
Seufert F, Pérez-Hernández G, Pándy-Szekeres G, Guixà-González R, Langenhan T, Gloriam DE, Hildebrand PW. Seufert F, et al. Among authors: hildebrand pw. Nat Commun. 2025 Jan 2;16(1):246. doi: 10.1038/s41467-024-55466-6. Nat Commun. 2025. PMID: 39747076 Free PMC article.
GPCRmd uncovers the dynamics of the 3D-GPCRome.
Rodríguez-Espigares I, Torrens-Fontanals M, Tiemann JKS, Aranda-García D, Ramírez-Anguita JM, Stepniewski TM, Worp N, Varela-Rial A, Morales-Pastor A, Medel-Lacruz B, Pándy-Szekeres G, Mayol E, Giorgino T, Carlsson J, Deupi X, Filipek S, Filizola M, Gómez-Tamayo JC, Gonzalez A, Gutiérrez-de-Terán H, Jiménez-Rosés M, Jespers W, Kapla J, Khelashvili G, Kolb P, Latek D, Marti-Solano M, Matricon P, Matsoukas MT, Miszta P, Olivella M, Perez-Benito L, Provasi D, Ríos S, R Torrecillas I, Sallander J, Sztyler A, Vasile S, Weinstein H, Zachariae U, Hildebrand PW, De Fabritiis G, Sanz F, Gloriam DE, Cordomi A, Guixà-González R, Selent J. Rodríguez-Espigares I, et al. Among authors: hildebrand pw. Nat Methods. 2020 Aug;17(8):777-787. doi: 10.1038/s41592-020-0884-y. Epub 2020 Jul 13. Nat Methods. 2020. PMID: 32661425
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.
Beliu G, Altrichter S, Guixà-González R, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW, Sauer M, Langenhan T. Beliu G, et al. Among authors: hildebrand pw. Mol Cell. 2021 Mar 4;81(5):905-921.e5. doi: 10.1016/j.molcel.2020.12.042. Epub 2021 Jan 25. Mol Cell. 2021. PMID: 33497605 Free article.
Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor.
Heng J, Hu Y, Pérez-Hernández G, Inoue A, Zhao J, Ma X, Sun X, Kawakami K, Ikuta T, Ding J, Yang Y, Zhang L, Peng S, Niu X, Li H, Guixà-González R, Jin C, Hildebrand PW, Chen C, Kobilka BK. Heng J, et al. Among authors: hildebrand pw. Nat Commun. 2023 Apr 10;14(1):2005. doi: 10.1038/s41467-023-37233-1. Nat Commun. 2023. PMID: 37037825 Free PMC article.
Membrane cholesterol access into a G-protein-coupled receptor.
Guixà-González R, Albasanz JL, Rodriguez-Espigares I, Pastor M, Sanz F, Martí-Solano M, Manna M, Martinez-Seara H, Hildebrand PW, Martín M, Selent J. Guixà-González R, et al. Among authors: hildebrand pw. Nat Commun. 2017 Feb 21;8:14505. doi: 10.1038/ncomms14505. Nat Commun. 2017. PMID: 28220900 Free PMC article.
Publisher Correction: GPCRmd uncovers the dynamics of the 3D-GPCRome.
Rodríguez-Espigares I, Torrens-Fontanals M, Tiemann JKS, Aranda-García D, Ramírez-Anguita JM, Stepniewski TM, Worp N, Varela-Rial A, Morales-Pastor A, Medel-Lacruz B, Pándy-Szekeres G, Mayol E, Giorgino T, Carlsson J, Deupi X, Filipek S, Filizola M, Gómez-Tamayo JC, Gonzalez A, Gutiérrez-de-Terán H, Jiménez-Rosés M, Jespers W, Kapla J, Khelashvili G, Kolb P, Latek D, Marti-Solano M, Matricon P, Matsoukas MT, Miszta P, Olivella M, Perez-Benito L, Provasi D, Ríos S, R Torrecillas I, Sallander J, Sztyler A, Vasile S, Weinstein H, Zachariae U, Hildebrand PW, De Fabritiis G, Sanz F, Gloriam DE, Cordomi A, Guixà-González R, Selent J. Rodríguez-Espigares I, et al. Among authors: hildebrand pw. Nat Methods. 2020 Aug;17(8):861-862. doi: 10.1038/s41592-020-0928-3. Nat Methods. 2020. PMID: 32704182
Time-resolved cryo-EM of G-protein activation by a GPCR.
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Papasergi-Scott MM, et al. Among authors: hildebrand pw. Nature. 2024 May;629(8014):1182-1191. doi: 10.1038/s41586-024-07153-1. Epub 2024 Mar 13. Nature. 2024. PMID: 38480881 Free PMC article.
Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor.
Batebi H, Pérez-Hernández G, Rahman SN, Lan B, Kamprad A, Shi M, Speck D, Tiemann JKS, Guixà-González R, Reinhardt F, Stadler PF, Papasergi-Scott MM, Skiniotis G, Scheerer P, Kobilka BK, Mathiesen JM, Liu X, Hildebrand PW. Batebi H, et al. Among authors: hildebrand pw. Nat Struct Mol Biol. 2024 Nov;31(11):1692-1701. doi: 10.1038/s41594-024-01334-2. Epub 2024 Jun 12. Nat Struct Mol Biol. 2024. PMID: 38867113
Structural basis for the interaction of the beta-secretase with copper.
Bittner HJ, Guixà-González R, Hildebrand PW. Bittner HJ, et al. Among authors: hildebrand pw. Biochim Biophys Acta Biomembr. 2018 May;1860(5):1105-1113. doi: 10.1016/j.bbamem.2018.01.019. Epub 2018 Jan 31. Biochim Biophys Acta Biomembr. 2018. PMID: 29391167 Free article.
84 results