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Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits.
Scherer N, Fässler D, Borisov O, Cheng Y, Schlosser P, Wuttke M, Haug S, Li Y, Telkämper F, Patil S, Meiselbach H, Wong C, Berger U, Sekula P, Hoppmann A, Schultheiss UT, Mozaffari S, Xi Y, Graham R, Schmidts M, Köttgen M, Oefner PJ, Knauf F, Eckardt KU, Grünert SC, Estrada K, Thiele I, Hertel J, Köttgen A. Scherer N, et al. Among authors: fassler d. Nat Genet. 2025 Jan 2. doi: 10.1038/s41588-024-01965-7. Online ahead of print. Nat Genet. 2025. PMID: 39747595
Keratin 17 modulates the immune topography of pancreatic cancer.
Delgado-Coka L, Horowitz M, Torrente-Goncalves M, Roa-Peña L, Leiton CV, Hasan M, Babu S, Fassler D, Oentoro J, Bai JK, Petricoin EF 3rd, Matrisian LM, Blais EM, Marchenko N, Allard FD, Jiang W, Larson B, Hendifar A, Chen C, Abousamra S, Samaras D, Kurc T, Saltz J, Escobar-Hoyos LF, Shroyer KR. Delgado-Coka L, et al. Among authors: fassler d. J Transl Med. 2024 May 10;22(1):443. doi: 10.1186/s12967-024-05252-1. J Transl Med. 2024. PMID: 38730319 Free PMC article.
Keratin 17 modulates the immune topography of pancreatic cancer.
Delgado-Coka LA, Horowitz M, Torrente-Goncalves M, Roa-Peña L, Leiton CV, Hasan M, Babu S, Fassler D, Oentoro J, Karen Bai JD, Petricoin EF, Matrisian LM, Blais EM, Marchenko N, Allard FD, Jiang W, Larson B, Hendifar A, Chen C, Abousamra S, Samaras D, Kurc T, Saltz J, Escobar-Hoyos LF, Shroyer K. Delgado-Coka LA, et al. Among authors: fassler d. Res Sq [Preprint]. 2024 Feb 20:rs.3.rs-3886691. doi: 10.21203/rs.3.rs-3886691/v1. Res Sq. 2024. Update in: J Transl Med. 2024 May 10;22(1):443. doi: 10.1186/s12967-024-05252-1 PMID: 38464123 Free PMC article. Updated. Preprint.
The Effects of Hospitalisation on the Serum Metabolome in COVID-19 Patients.
Hensen T, Fässler D, O'Mahony L, Albrich WC, Barda B, Garzoni C, Kleger GR, Pietsch U, Suh N, Hertel J, Thiele I. Hensen T, et al. Among authors: fassler d. Metabolites. 2023 Aug 16;13(8):951. doi: 10.3390/metabo13080951. Metabolites. 2023. PMID: 37623894 Free PMC article.
NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health.
Hertel J, Fässler D, Heinken A, Weiß FU, Rühlemann M, Bang C, Franke A, Budde K, Henning AK, Petersmann A, Völker U, Völzke H, Thiele I, Grabe HJ, Lerch MM, Nauck M, Friedrich N, Frost F. Hertel J, et al. Among authors: fassler d. Metabolites. 2022 Mar 31;12(4):308. doi: 10.3390/metabo12040308. Metabolites. 2022. PMID: 35448495 Free PMC article.
Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
Steubler V, Erdinger S, Back MK, Ludewig S, Fässler D, Richter M, Han K, Slomianka L, Amrein I, von Engelhardt J, Wolfer DP, Korte M, Müller UC. Steubler V, et al. Among authors: fassler d. EMBO J. 2021 Jun 15;40(12):e107471. doi: 10.15252/embj.2020107471. Epub 2021 May 19. EMBO J. 2021. PMID: 34008862 Free PMC article.
38 results