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Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans.
Isaac AR, Chauvet MG, Lima-Filho R, Wagner BA, Caroli BG, Leite REP, Suemoto CK, Nunes PV, De Felice FG, Ferreira ST, Lourenco MV. Isaac AR, et al. Among authors: lourenco mv. Transl Psychiatry. 2024 Oct 1;14(1):397. doi: 10.1038/s41398-024-03128-y. Transl Psychiatry. 2024. PMID: 39349438 Free PMC article.
The ketamine metabolite (2R,6R)-hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease.
Ribeiro FC, Cozachenco D, Argyrousi EK, Staniszewski A, Wiebe S, Calixtro JD, Soares-Neto R, Al-Chami A, Sayegh FE, Bermudez S, Arsenault E, Cossenza M, Lacaille JC, Nader K, Sun H, De Felice FG, Lourenco MV, Arancio O, Aguilar-Valles A, Sonenberg N, Ferreira ST. Ribeiro FC, et al. Among authors: lourenco mv. Alzheimers Dement. 2024 Aug;20(8):5398-5410. doi: 10.1002/alz.14034. Epub 2024 Jun 27. Alzheimers Dement. 2024. PMID: 38934107 Free PMC article.
Cross-species comparative hippocampal transcriptomics in Alzheimer's disease.
De Bastiani MA, Bellaver B, Carello-Collar G, Zimmermann M, Kunach P, Lima-Filho RAS, Forner S, Martini AC, Pascoal TA, Lourenco MV, Rosa-Neto P, Zimmer ER. De Bastiani MA, et al. Among authors: lourenco mv. iScience. 2023 Dec 7;27(1):108671. doi: 10.1016/j.isci.2023.108671. eCollection 2024 Jan 19. iScience. 2023. PMID: 38292167 Free PMC article.
Association of the fibronectin type III domain-containing protein 5 rs1746661 single nucleotide polymorphism with reduced brain glucose metabolism in elderly humans.
Lima-Filho RAS, Benedet AL, De Bastiani MA, Povala G, Cozachenco D, Ferreira ST, De Felice FG, Rosa-Neto P, Zimmer ER, Lourenco MV; Alzheimer’s Disease Neuroimaging Initiative. Lima-Filho RAS, et al. Among authors: lourenco mv. Brain Commun. 2023 Aug 17;5(4):fcad216. doi: 10.1093/braincomms/fcad216. eCollection 2023. Brain Commun. 2023. PMID: 37601408 Free PMC article.
54 results