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The Abca7V1613M variant reduces Aβ generation, plaque load, and neuronal damage.
Butler CA, Mendoza Arvilla A, Milinkeviciute G, Da Cunha C, Kawauchi S, Rezaie N, Liang HY, Javonillo D, Thach A, Wang S, Collins S, Walker A, Shi KX, Neumann J, Gomez-Arboledas A, Henningfield CM, Hohsfield LA, Mapstone M, Tenner AJ, LaFerla FM, Mortazavi A, MacGregor GR, Green KN. Butler CA, et al. Among authors: mendoza arvilla a. Alzheimers Dement. 2024 Jul;20(7):4914-4934. doi: 10.1002/alz.13783. Epub 2024 Mar 20. Alzheimers Dement. 2024. PMID: 38506634 Free PMC article.
C5aR1 antagonism suppresses inflammatory glial gene expression and alters cellular signaling in an aggressive Alzheimer's model.
Schartz ND, Liang HY, Carvalho K, Chu SH, Mendoza-Arvilla A, Petrisko TJ, Gomez-Arboledas A, Mortazavi A, Tenner AJ. Schartz ND, et al. Among authors: mendoza arvilla a. bioRxiv [Preprint]. 2023 Aug 22:2023.08.22.554306. doi: 10.1101/2023.08.22.554306. bioRxiv. 2023. Update in: Nat Commun. 2024 Aug 15;15(1):7028. doi: 10.1038/s41467-024-51163-6 PMID: 37662399 Free PMC article. Updated. Preprint.