Huang R - Search Results

1

Decoding the protein methylome: Identification, validation, and functional insights.

Meng Y, Huang R. Meng Y, et al. Among authors: huang r. Bioorg Med Chem. 2025 Feb 1;118:118056. doi: 10.1016/j.bmc.2024.118056. Epub 2024 Dec 28. Bioorg Med Chem. 2025. PMID: 39754853 Review.

2

Structure-Activity Relationship Studies of Venglustat on NTMT1 Inhibition.

Deng Y, Dong G, Meng Y, Noinaj N, Huang R. Deng Y, et al. Among authors: huang r. J Med Chem. 2023 Jan 26;66(2):1601-1615. doi: 10.1021/acs.jmedchem.2c01854. Epub 2023 Jan 12. J Med Chem. 2023. PMID: 36634151 Free PMC article.

3

Past, present, and perspectives of protein N-terminal methylation.

Diaz K, Meng Y, Huang R. Diaz K, et al. Among authors: huang r. Curr Opin Chem Biol. 2021 Aug;63:115-122. doi: 10.1016/j.cbpa.2021.02.017. Epub 2021 Apr 8. Curr Opin Chem Biol. 2021. PMID: 33839647 Free PMC article. Review.

4

Site-specific methylation on α-N-terminus of peptides through chemical and enzymatic methods.

Meng Y, Huang R. Meng Y, et al. Among authors: huang r. Methods Enzymol. 2023;684:113-133. doi: 10.1016/bs.mie.2023.02.008. Epub 2023 Mar 24. Methods Enzymol. 2023. PMID: 37230586 Free PMC article.

5

Characterizations of Protein Arginine Deiminase 1 as a Substrate of NTMT1: Implications of Nα-Methylation in Protein Stability and Interaction.

Meng Y, Li Z, He M, Zhang Q, Deng Y, Wang Y, Huang R. Meng Y, et al. Among authors: huang r. J Proteome Res. 2024 Oct 4;23(10):4589-4600. doi: 10.1021/acs.jproteome.4c00484. Epub 2024 Sep 17. J Proteome Res. 2024. PMID: 39287128

6

Chemoproteomic Study Uncovers HemK2/KMT9 As a New Target for NTMT1 Bisubstrate Inhibitors.

Chen D, Meng Y, Yu D, Noinaj N, Cheng X, Huang R. Chen D, et al. Among authors: huang r. ACS Chem Biol. 2021 Jul 16;16(7):1234-1242. doi: 10.1021/acschembio.1c00279. Epub 2021 Jun 30. ACS Chem Biol. 2021. PMID: 34192867 Free PMC article.

7

Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity.

Meng Y, Iyamu ID, Ahmed NAM, Huang R. Meng Y, et al. Among authors: huang r. ACS Chem Biol. 2024 Jan 19;19(1):89-100. doi: 10.1021/acschembio.3c00531. Epub 2024 Jan 5. ACS Chem Biol. 2024. PMID: 38181447

8

An Adenosine Analogue Library Reveals Insights into Active Sites of Protein Arginine Methyltransferases and Enables the Discovery of a Selective PRMT4 Inhibitor.

Deng Y, Kim EJ, Song X, Kulkarni AS, Zhu RX, Wang Y, Bush M, Dong A, Noinaj N, Min J, Xu W, Huang R. Deng Y, et al. Among authors: huang r. J Med Chem. 2024 Oct 24;67(20):18053-18069. doi: 10.1021/acs.jmedchem.4c01041. Epub 2024 Oct 3. J Med Chem. 2024. PMID: 39361813

9

Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1.

Chen D, Dong G, Noinaj N, Huang R. Chen D, et al. Among authors: huang r. J Med Chem. 2019 Apr 11;62(7):3773-3779. doi: 10.1021/acs.jmedchem.9b00206. Epub 2019 Mar 27. J Med Chem. 2019. PMID: 30883119 Free PMC article.

10

Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner.

Dong G, Deng Y, Yasgar A, Yadav R, Talley D, Zakharov AV, Jain S, Rai G, Noinaj N, Simeonov A, Huang R. Dong G, et al. Among authors: huang r. J Med Chem. 2022 Sep 22;65(18):12334-12345. doi: 10.1021/acs.jmedchem.2c01050. Epub 2022 Sep 8. J Med Chem. 2022. PMID: 36074125 Free PMC article.

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