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HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma.
Turnham RE, Pitea A, Jang GM, Xu Z, Lim HC, Choi AL, Von Dollen J, Levin RS, Webber JT, McCarthy E, Hu J, Li X, Che L, Singh A, Yoon A, Chan G, Kelley RK, Swaney DL, Zhang W, Bandyopadhyay S, Theis FJ, Eckhardt M, Chen X, Shokat KM, Ideker T, Krogan NJ, Gordan JD. Turnham RE, et al. Among authors: shokat km. Cancer Res. 2024 Dec 9. doi: 10.1158/0008-5472.CAN-24-0456. Online ahead of print. Cancer Res. 2024. PMID: 39652575
Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.
Morstein J, Bowcut V, Fernando M, Yang Y, Zhu L, Jenkins ML, Evans JT, Guiley KZ, Peacock DM, Krahnke S, Lin Z, Taran KA, Huang BJ, Stephen AG, Burke JE, Lightstone FC, Shokat KM. Morstein J, et al. Among authors: shokat km. Cell. 2024 Oct 31;187(22):6379-6392.e17. doi: 10.1016/j.cell.2024.08.017. Epub 2024 Sep 9. Cell. 2024. PMID: 39255801 Free PMC article.
Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib.
Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, Shah NP. Leyte-Vidal A, et al. Among authors: shokat km. Leukemia. 2024 Sep;38(9):2046-2050. doi: 10.1038/s41375-024-02353-0. Epub 2024 Jul 31. Leukemia. 2024. PMID: 39085402 Free PMC article. No abstract available.
Direct RAS inhibitors turn 10.
Ostrem JML, Peters U, Shokat KM. Ostrem JML, et al. Among authors: shokat km. Nat Chem Biol. 2024 Oct;20(10):1238-1241. doi: 10.1038/s41589-024-01691-5. Nat Chem Biol. 2024. PMID: 39060392 No abstract available.
Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes.
Malakoutikhah M, Mahran R, Gooran N, Masoumi A, Lundell K, Liljeblad A, Guiley K, Dai S, Zheng Q, Zhu L, Shokat KM, Kopra K, Härmä H. Malakoutikhah M, et al. Among authors: shokat km. Anal Chem. 2023 Dec 19;95(50):18344-18351. doi: 10.1021/acs.analchem.3c02844. Epub 2023 Dec 7. Anal Chem. 2023. PMID: 38060502 Free PMC article.
360 results