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Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST.
Kraus F, He Y, Swarup S, Overmyer KA, Jiang Y, Brenner J, Capitanio C, Bieber A, Jen A, Nightingale NM, Anderson BJ, Lee C, Paulo JA, Smith IR, Plitzko JM, Gygi SP, Schulman BA, Wilfling F, Coon JJ, Harper JW. Kraus F, et al. Among authors: gygi sp. Sci Adv. 2025 Jan 24;11(4):eadu5787. doi: 10.1126/sciadv.adu5787. Epub 2025 Jan 22. Sci Adv. 2025. PMID: 39841834 Free article.
CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.
Fleming TJ, Antoszewski M, Lambo S, Gundry MC, Piussi R, Wahlster L, Shah S, Reed FE, Dong KD, Paulo JA, Gygi SP, Mimoso C, Goldman SR, Adelman K, Perry JA, Pikman Y, Stegmaier K, Barrachina MN, Machlus KR, Hovestadt V, Arruda A, Minden MD, Voit RA, Sankaran VG. Fleming TJ, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Dec 30:2024.12.30.630680. doi: 10.1101/2024.12.30.630680. bioRxiv. 2024. PMID: 39803492 Free PMC article. Preprint.
Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity.
Latorre-Muro P, Vitale T, Ravichandran M, Zhang K, Palozzi JM, Bennett CF, Lamas-Paz A, Sohn JH, Jackson TD, Jedrychowski M, Gygi SP, Kajimura S, Schmoker A, Jeon H, Eck MJ, Puigserver P. Latorre-Muro P, et al. Among authors: gygi sp. Nat Cell Biol. 2025 Jan;27(1):130-140. doi: 10.1038/s41556-024-01555-z. Epub 2025 Jan 3. Nat Cell Biol. 2025. PMID: 39753947
USP14 inhibition enhances Parkin-independent mitophagy in iNeurons.
Bernardo G, Prado MA, Dashtmian AR, Favaro M, Mauri S, Borsetto A, Marchesan E, Paulo JA, Gygi SP, Finley DJ, Ziviani E. Bernardo G, et al. Among authors: gygi sp. Pharmacol Res. 2024 Dec;210:107484. doi: 10.1016/j.phrs.2024.107484. Epub 2024 Oct 30. Pharmacol Res. 2024. PMID: 39486496 Free article.
Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.
Cluntun AA, Visker JR, Velasco-Silva JN, Lang MJ, Cedeño-Rosario L, Shankar TS, Hamouche R, Ling J, Kim JE, Toshniwal AG, Low HK, Cunningham CN, Carrington J, Catrow JL, Pearce Q, Jeong MY, Bott AJ, Narbona-Pérez ÁJ, Stanley CE, Li Q, Eberhardt DR, Morgan JT, Yadav T, Wells CE, Ramadurai DKA, Swiatek WI, Chaudhuri D, Rothstein JD, Muoio DM, Paulo JA, Gygi SP, Baker SA, Navankasattusas S, Cox JE, Funai K, Drakos SG, Rutter J, Ducker GS. Cluntun AA, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Oct 8:2024.10.07.617073. doi: 10.1101/2024.10.07.617073. bioRxiv. 2024. PMID: 39416192 Free PMC article. Preprint.
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