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Amino acids and KLHL22 do not activate mTORC1 via DEPDC5 degradation.
Valenstein ML, Lalgudi PV, Kedir JF, Condon KJ, Platzek A, Freund DG, Taylor MS, Xu Y, Chivukula RR, Sabatini DM. Valenstein ML, et al. Among authors: sabatini dm. Nature. 2025 Jan;637(8045):E11-E14. doi: 10.1038/s41586-024-07974-0. Epub 2025 Jan 8. Nature. 2025. PMID: 39780017 No abstract available.
Lysosomal reduced thiols are essential for mouse embryonic development.
Adelmann CH, Venkatachalam A, Huang L, Liu M, Germana S, Sabatini DM, Fisher DE. Adelmann CH, et al. Among authors: sabatini dm. bioRxiv [Preprint]. 2024 Dec 26:2024.12.26.630348. doi: 10.1101/2024.12.26.630348. bioRxiv. 2024. PMID: 39764028 Free PMC article. Preprint.
Technologies for Decoding Cancer Metabolism with Spatial Resolution.
Chen WW, Pacold ME, Sabatini DM, Kanarek N. Chen WW, et al. Among authors: sabatini dm. Cold Spring Harb Perspect Med. 2024 Sep 16:a041553. doi: 10.1101/cshperspect.a041553. Online ahead of print. Cold Spring Harb Perspect Med. 2024. PMID: 39284668
Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM. Sprenger HG, et al. Among authors: sabatini dm. bioRxiv [Preprint]. 2024 Apr 10:2024.04.10.588849. doi: 10.1101/2024.04.10.588849. bioRxiv. 2024. PMID: 38645260 Free PMC article. Preprint.
CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.
Laqtom NN, Dong W, Medoh UN, Cangelosi AL, Dharamdasani V, Chan SH, Kunchok T, Lewis CA, Heinze I, Tang R, Grimm C, Dang Do AN, Porter FD, Ori A, Sabatini DM, Abu-Remaileh M. Laqtom NN, et al. Among authors: sabatini dm. Nature. 2022 Sep;609(7929):1005-1011. doi: 10.1038/s41586-022-05221-y. Epub 2022 Sep 21. Nature. 2022. PMID: 36131016 Free PMC article.
265 results