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Serotonin 3 receptor signaling regulates 5-fluorouracil-mediated apoptosis indirectly via TNF-α production by enhancing serotonin release from enterochromaffin cells.
Mikawa S, Kondo M, Kaji N, Mihara T, Yoshitake R, Nakagawa T, Takamoto M, Nishimura R, Shimada S, Ozaki H, Hori M. Mikawa S, et al. Among authors: mihara t. FASEB J. 2019 Feb;33(2):1669-1680. doi: 10.1096/fj.201701200RR. Epub 2018 Sep 12. FASEB J. 2019. PMID: 30207796
In conclusion, 5-HT(3)R signaling may enhance 5-HT release, possibly from EC cells intravascularly, or paracrine, resulting in increases in plasma 5-HT concentration, which in turn, enhances apoptotic activities induced by 5-FU.-Mikawa, S., Kondo, M., Kaji, N., Mihara, …
In conclusion, 5-HT(3)R signaling may enhance 5-HT release, possibly from EC cells intravascularly, or paracrine, resulting in increases in …
408 results