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Activation of SIRT1 by SRT1720 Alleviates Dyslipidemia, Improves Insulin Sensitivity and Exhibits Liver-Protective Effects in Diabetic Rats on a High-Fat Diet: New Insights into the SIRT1/Nrf2/NFκB Signaling Pathway.
Elmorsy EA, Elsisi HA, Alkhamiss AS, Alsoqih NS, Khodeir MM, Alsalloom AA, Almeman AA, Elghandour SR, Nadwa EH, Khalifa AK, Khaled BEA, Ramadan A, Kamal MM, Alsaeed TS, Alharbi MS, Abdel-Moneim AH, Ellethy AT, Saber S. Elmorsy EA, et al. Among authors: ellethy at. Eur J Pharm Sci. 2025 Jan 6:107002. doi: 10.1016/j.ejps.2025.107002. Online ahead of print. Eur J Pharm Sci. 2025. PMID: 39778687
Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles.
Elmorsy EA, Youssef ME, Abdel-Hamed MR, Amer MM, Elghandour SR, Alkhamiss AS, Mohamed NB, Khodeir MM, Elsisi HA, Alsaeed TS, Kamal MM, Ellethy AT, Elesawy BH, Saber S. Elmorsy EA, et al. Among authors: ellethy at. Front Pharmacol. 2024 Sep 18;15:1456058. doi: 10.3389/fphar.2024.1456058. eCollection 2024. Front Pharmacol. 2024. PMID: 39359253 Free PMC article.
STA-9090 in combination with a statin exerts enhanced protective effects in rats fed a high-fat diet and exposed to diethylnitrosamine and thioacetamide.
Abdelhamid AM, Saber S, Hamad RS, Abdel-Reheim MA, Ellethy AT, Amer MM, Abdel-Hamed MR, Mohamed EA, Ahmed SS, Elsisi HA, Khodeir MM, Alkhamiss AS, A AA, Abu Elgasim MAE, Almansour ZH, Elesawy BH, Elmorsy EA. Abdelhamid AM, et al. Among authors: ellethy at. Front Pharmacol. 2024 Sep 4;15:1454829. doi: 10.3389/fphar.2024.1454829. eCollection 2024. Front Pharmacol. 2024. PMID: 39309001 Free PMC article.
Hedgehog signaling is a promising target for the treatment of hepatic fibrogenesis: a new management strategy using itraconazole-loaded nanoparticles.
Elmorsy EA, Saber S, Kira AY, Alghasham A, Abdel-Hamed MR, Amer MM, Mohamed EA, AlSalloom A A, Alkhamiss AS, Hamad RS, Abdel-Reheim MA, Ellethy AT, Elsisi HA, Alsharidah M, Elghandour SR, Elnawawy T, Abdelhady R. Elmorsy EA, et al. Among authors: ellethy at. Front Pharmacol. 2024 May 14;15:1377980. doi: 10.3389/fphar.2024.1377980. eCollection 2024. Front Pharmacol. 2024. PMID: 38808257 Free PMC article.