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Modulation of Mitochondria-Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model.
Etxebeste-Mitxeltorena M, Flores-Romero H, Ramos-Inza S, Masiá E, Nenchova M, Montesinos J, Martinez-Gonzalez L, Porras G, Orzáez M, Vicent MJ, Gil C, Area-Gomez E, Garcia-Saez AJ, Martinez A. Etxebeste-Mitxeltorena M, et al. Among authors: garcia saez aj. J Med Chem. 2025 Jan 23;68(2):1179-1194. doi: 10.1021/acs.jmedchem.4c01368. Epub 2025 Jan 8. J Med Chem. 2025. PMID: 39778888
Lipids glue BAK dimers together.
Flores-Romero H, García-Sáez AJ. Flores-Romero H, et al. Nat Struct Mol Biol. 2020 Nov;27(11):1003-1004. doi: 10.1038/s41594-020-00516-y. Nat Struct Mol Biol. 2020. PMID: 32994578 No abstract available.
The Mysteries around the BCL-2 Family Member BOK.
Shalaby R, Flores-Romero H, García-Sáez AJ. Shalaby R, et al. Biomolecules. 2020 Dec 4;10(12):1638. doi: 10.3390/biom10121638. Biomolecules. 2020. PMID: 33291826 Free PMC article. Review.
Pore formation in regulated cell death.
Flores-Romero H, Ros U, Garcia-Saez AJ. Flores-Romero H, et al. EMBO J. 2020 Dec 1;39(23):e105753. doi: 10.15252/embj.2020105753. Epub 2020 Oct 30. EMBO J. 2020. PMID: 33124082 Free PMC article. Review.
MAVS-induced mitochondrial membrane remodeling.
Flores-Romero H, García-Sáez AJ. Flores-Romero H, et al. FEBS J. 2019 Apr;286(8):1540-1542. doi: 10.1111/febs.14822. Epub 2019 Apr 8. FEBS J. 2019. PMID: 30957952 Free article.
A lipid perspective on regulated cell death.
Flores-Romero H, Ros U, García-Sáez AJ. Flores-Romero H, et al. Int Rev Cell Mol Biol. 2020;351:197-236. doi: 10.1016/bs.ircmb.2019.11.004. Epub 2019 Dec 18. Int Rev Cell Mol Biol. 2020. PMID: 32247580 Review.
Membrane promotes tBID interaction with BCL(XL).
García-Sáez AJ, Ries J, Orzáez M, Pérez-Payà E, Schwille P. García-Sáez AJ, et al. Nat Struct Mol Biol. 2009 Nov;16(11):1178-85. doi: 10.1038/nsmb.1671. Epub 2009 Oct 11. Nat Struct Mol Biol. 2009. PMID: 19820711 Free article.
The Incomplete Puzzle of the BCL2 Proteins.
Flores-Romero H, García-Sáez AJ. Flores-Romero H, et al. Cells. 2019 Sep 29;8(10):1176. doi: 10.3390/cells8101176. Cells. 2019. PMID: 31569576 Free PMC article. Review.
137 results