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TAK-994 Mechanistic Investigation into Drug-Induced Liver Injury.
Shinozawa T, Miyamoto K, Baker KS, Faber SC, Flores R, Uetrecht J, von Hehn C, Yukawa T, Tohyama K, Kadali H, von Grotthuss M, Sudo Y, Smith EN, Diogo D, Zhu AZX, Dragan Y, Cebers G, Wagoner MP. Shinozawa T, et al. Among authors: dragan y. Toxicol Sci. 2025 Jan 9:kfaf003. doi: 10.1093/toxsci/kfaf003. Online ahead of print. Toxicol Sci. 2025. PMID: 39786842
Polygenic architecture informs potential vulnerability to drug-induced liver injury.
Koido M, Kawakami E, Fukumura J, Noguchi Y, Ohori M, Nio Y, Nicoletti P, Aithal GP, Daly AK, Watkins PB, Anayama H, Dragan Y, Shinozawa T, Takebe T. Koido M, et al. Among authors: dragan y. Nat Med. 2020 Oct;26(10):1541-1548. doi: 10.1038/s41591-020-1023-0. Epub 2020 Sep 7. Nat Med. 2020. PMID: 32895570 Free PMC article.
Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.
Longo DM, Woodhead JL, Walker P, Herédi-Szabó K, Mogyorósi K, Wolenski FS, Dragan YP, Mosedale M, Siler SQ, Watkins PB, Howell BA. Longo DM, et al. Among authors: dragan yp. Toxicol Sci. 2019 Feb 1;167(2):458-467. doi: 10.1093/toxsci/kfy253. Toxicol Sci. 2019. PMID: 30289550 Free PMC article.
Evaluation of Temporal Changes in Urine-based Metabolomic and Kidney Injury Markers to Detect Compound Induced Acute Kidney Tubular Toxicity in Beagle Dogs.
Wagoner MP, Yang Y, McDuffie JE, Klapczynski M, Buck W, Cheatham L, Eisinger D, Sace F, Lynch KM, Sonee M, Ma JY, Chen Y, Marshall K, Damour M, Stephen L, Dragan YP, Fikes J, Snook S, Kinter LB. Wagoner MP, et al. Among authors: dragan yp. Curr Top Med Chem. 2017;17(24):2767-2780. doi: 10.2174/1568026617666170713172331. Curr Top Med Chem. 2017. PMID: 28714420
Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.
Ewart L, Fabre K, Chakilam A, Dragan Y, Duignan DB, Eswaraka J, Gan J, Guzzie-Peck P, Otieno M, Jeong CG, Keller DA, de Morais SM, Phillips JA, Proctor W, Sura R, Van Vleet T, Watson D, Will Y, Tagle D, Berridge B. Ewart L, et al. Among authors: dragan y. Exp Biol Med (Maywood). 2017 Oct;242(16):1579-1585. doi: 10.1177/1535370217715441. Epub 2017 Jun 16. Exp Biol Med (Maywood). 2017. PMID: 28622731 Free PMC article.
105 results