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Oxidative and Excitatory Neurotoxic Stresses in CRISPR/Cas9-Induced Kynurenine Aminotransferase Knockout Mice: A Novel Model for Despair-Based Depression and Post-Traumatic Stress Disorder.
Szabó Á, Galla Z, Spekker E, Szűcs M, Martos D, Takeda K, Ozaki K, Inoue H, Yamamoto S, Toldi J, Ono E, Vécsei L, Tanaka M. Szabó Á, et al. Front Biosci (Landmark Ed). 2025 Jan 20;30(1):25706. doi: 10.31083/FBL25706. Front Biosci (Landmark Ed). 2025. PMID: 39862084 Free article.
Plasma metabolite levels are generally consistent with those of urine: antioxidant KYNs, 5-hydroxyindoleacetic acid, and indole-3-acetic acid levels were lower; enzyme activities in KATs, kynureninase, and monoamine oxidase/aldehyde dehydrogenase were lower, but kyn …
Plasma metabolite levels are generally consistent with those of urine: antioxidant KYNs, 5-hydroxyindoleacetic acid, and indole-3-acetic aci …
Acute Toxicity and Neuroprotective Effect of "RJ6601", a Newly Formulated Instant Soup, in Geriatric Rats.
Chaisanam R, Wattanathorn J. Chaisanam R, et al. Foods. 2025 Jan 16;14(2):277. doi: 10.3390/foods14020277. Foods. 2025. PMID: 39856944 Free article.
At the end of the study period, assessments were conducted to evaluate the neuron density; MDA levels; and activities of SOD, CAT, GSH-Px, AChE, total MAO, MAO-A, and MAO-B in the hippocampus. Our results reveal increased neuron density, SOD, CAT, and GSH-Px but dec …
At the end of the study period, assessments were conducted to evaluate the neuron density; MDA levels; and activities of SOD, CAT, GSH-Px, A …
[Pseudomonas monteilii ZMU-T06 produces 2-substituted quinolines by oxidative dehydroaromatization].
Yang M, Zou L, Ran H, Qin L. Yang M, et al. Sheng Wu Gong Cheng Xue Bao. 2025 Jan 25;41(1):288-295. doi: 10.13345/j.cjb.240359. Sheng Wu Gong Cheng Xue Bao. 2025. PMID: 39855694 Free article. Chinese.
We mined a strain Pseudomonas monteilii ZMU-T06 capable of producing monoamine oxidase for the dehydroaromatization of 2-substituted-1,2,3,4-tetrahydroquinolines to synthesize 2-substituted quinolines (8 substrates, yields of 45.7%-48.4%) and then hypothesized the c …
We mined a strain Pseudomonas monteilii ZMU-T06 capable of producing monoamine oxidase for the dehydroaromatization of 2-subst …
HYDROGEN SULFIDE AND CYSTATHIONINE γ-LYASE LEVELS FOR PATIENTS WITH PARKINSON'S DISEASE.
Al-Taee K, Al-Helaly L. Al-Taee K, et al. Georgian Med News. 2024 Nov;(356):136-140. Georgian Med News. 2024. PMID: 39855178
The research includes studying the levels of hydrogen sulphide (H2S) and cystathionine gamma-lyase (CSE) with some biochemical parameters in the serum of patients with PD in Mosul City (Iraq), which include Serotonin (SERT), dopamine (DA), sphingomyelin (SM), vitamin B12, Acetylc …
The research includes studying the levels of hydrogen sulphide (H2S) and cystathionine gamma-lyase (CSE) with some biochemical parameters in …
Preparation of Ethosome Gel with Total Flavonoids from Vernonia anthelmintica (L.) Willd. for the Treatment of Vitiligo.
Qin D, Cui Y, Zheng M, Yang Z, Wang X. Qin D, et al. Gels. 2025 Jan 17;11(1):73. doi: 10.3390/gels11010073. Gels. 2025. PMID: 39852044 Free article.
Histological examinations performed through hematoxylin and eosin (H&E) staining of mouse skin revealed increased melanin production and increased activities of tyrosinase (TYR), cholinesterase (CHE), and mouse monoamine oxidase (MAO), while levels of superoxide …
Histological examinations performed through hematoxylin and eosin (H&E) staining of mouse skin revealed increased melanin production and …
Deep learning-based drug screening for the discovery of potential therapeutic agents for Alzheimer's disease.
Wu T, Lin R, Cui P, Yong J, Yu H, Li Z. Wu T, et al. J Pharm Anal. 2024 Oct;14(10):101022. doi: 10.1016/j.jpha.2024.101022. Epub 2024 Jun 13. J Pharm Anal. 2024. PMID: 39850238 Free PMC article.
The AD model was trained with compounds labeled for AD activity to predict active compounds at the disease level, while the acetylcholinesterase (AChE), monoamine oxidase-A (MAO-A), and 5-hydroxytryptamine 6 (5-HT(6)) models were trained for specific A …
The AD model was trained with compounds labeled for AD activity to predict active compounds at the disease level, while the acetylcholineste …
Mace Poisoning: Accidental Toxic Ingestion in a Child Leading to a Reversible Coma.
Imtiaz A, Almutairy BM, Almutairi TM, Aloufi MM, Almutairi AH. Imtiaz A, et al. Cureus. 2024 Dec 23;16(12):e76284. doi: 10.7759/cureus.76284. eCollection 2024 Dec. Cureus. 2024. PMID: 39850188 Free PMC article.
Myristicin acts by moderately inhibiting monoamine oxidase, causing anticholinergic symptoms. It also leads to the formation of the metabolite 3-methoxy-4,5-methylendioxy amphetamine (MMDA), responsible for its psychedelic effects. ...
Myristicin acts by moderately inhibiting monoamine oxidase, causing anticholinergic symptoms. It also leads to the formation o …
High-prediction QSAR Modeling Study Based on the Efficacy of a Novel 6-hydroxybenzothiazole-2-carboxamide Targeted Monoamine Oxidase B in the Treatment of Neurodegenerative Diseases.
Xie D, Cai Z, Mao J, Qu X, Cao L, Zhou J. Xie D, et al. Med Chem. 2025 Jan 20. doi: 10.2174/0115734064364749250102024805. Online ahead of print. Med Chem. 2025. PMID: 39838656
These diseases are closely associated with increased expression of monoamine oxidase B (MAO-B), an important enzyme that regulates neurotransmitter concentration, and its overactivity leads to oxidative stress and neurotoxicity, accelerating the progression of neuro …
These diseases are closely associated with increased expression of monoamine oxidase B (MAO-B), an important enzyme that regul …
Dual inhibition of AChE and MAO-B in Alzheimer's disease: machine learning approaches and model interpretations.
Hou Q, Li Y. Hou Q, et al. Mol Divers. 2025 Jan 21. doi: 10.1007/s11030-024-11061-x. Online ahead of print. Mol Divers. 2025. PMID: 39838228
Given the multifactorial pathophysiology of AD, monotargeted agents can only alleviate symptoms but not cure AD. Acetylcholinesterase (AChE) and Monoamine oxidase B (MAO-B) are two key targets in the treatment of AD, molecules that inhibiting both targets are consid …
Given the multifactorial pathophysiology of AD, monotargeted agents can only alleviate symptoms but not cure AD. Acetylcholinesterase (AChE) …
26,580 results
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