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LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling.
Schelker RC, Fioravanti J, Mastrogiovanni F, Baldwin JG, Rana N, Li P, Chen P, Vadász T, Spolski R, Heuser-Loy C, Slavkovic-Lukic D, Noronha P, Damiano G, Raccosta L, Maggioni D, Pullugula S, Lin JX, Oh J, Grandinetti P, Lecce M, Hesse L, Kocks E, Martín-Santos A, Gebhard C, Telford WG, Ji Y, Restifo NP, Russo V, Rehli M, Herr W, Leonard WJ, Gattinoni L. Schelker RC, et al. Among authors: spolski r. Signal Transduct Target Ther. 2024 Aug 9;9(1):199. doi: 10.1038/s41392-024-01915-z. Signal Transduct Target Ther. 2024. PMID: 39117617 Free PMC article.
Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function.
Spolski R, Li P, Chandra V, Shin B, Goel S, Sakamoto K, Liu C, Oh J, Ren M, Enomoto Y, West EE, Christensen SM, Wan ECK, Ge M, Lin JX, Yan B, Kazemian M, Yu ZX, Nagao K, Vijayanand P, Rothenberg EV, Leonard WJ. Spolski R, et al. Sci Immunol. 2023 Nov 3;8(89):eadi8217. doi: 10.1126/sciimmunol.adi8217. Epub 2023 Nov 3. Sci Immunol. 2023. PMID: 37922339 Free PMC article.
An engineered IL-2 partial agonist promotes CD8+ T cell stemness.
Mo F, Yu Z, Li P, Oh J, Spolski R, Zhao L, Glassman CR, Yamamoto TN, Chen Y, Golebiowski FM, Hermans D, Majri-Morrison S, Picton LK, Liao W, Ren M, Zhuang X, Mitra S, Lin JX, Gattinoni L, Powell JD, Restifo NP, Garcia KC, Leonard WJ. Mo F, et al. Among authors: spolski r. Nature. 2021 Sep;597(7877):544-548. doi: 10.1038/s41586-021-03861-0. Epub 2021 Sep 15. Nature. 2021. PMID: 34526724 Free PMC article.
Cushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis, and rescue by IL-21.
Hwang S, Tatsi C, Kuehn HS, Niemela JE, Stoddard J, Su Y, Lodish M, Uzel G, Spolski R, Leonard WJ, Holland SM, Fleisher TA, Stratakis CA, Rosenzweig SD. Hwang S, et al. Among authors: spolski r. J Allergy Clin Immunol. 2022 Jan;149(1):302-314. doi: 10.1016/j.jaci.2021.05.031. Epub 2021 Jun 2. J Allergy Clin Immunol. 2022. PMID: 34089750 Free PMC article.
93 results