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Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines.
Manville RW, Yoshimura RF, Yeromin AV, Hogenkamp D, van der Horst J, Zavala A, Chinedu S, Arena G, Lasky E, Fisher M, Tracy CR, Othy S, Jepps TA, Cahalan MD, Abbott GW. Manville RW, et al. Among authors: yoshimura rf. Commun Biol. 2024 Aug 28;7(1):1059. doi: 10.1038/s42003-024-06752-y. Commun Biol. 2024. PMID: 39198706 Free PMC article.
KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics.
Abbott GW, Redford KE, Yoshimura RF, Manville RW, Moreira L, Tran K, Arena G, Kookootsedes A, Lasky E, Gunnison E. Abbott GW, et al. Among authors: yoshimura rf. Front Physiol. 2021 Nov 11;12:777057. doi: 10.3389/fphys.2021.777057. eCollection 2021. Front Physiol. 2021. PMID: 34858215 Free PMC article.
Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.
Hogenkamp DJ, Ford-Hutchinson TA, Li WY, Whittemore ER, Yoshimura RF, Tran MB, Johnstone TB, Bascom GD, Rollins H, Lu L, Gee KW. Hogenkamp DJ, et al. Among authors: yoshimura rf. J Med Chem. 2013 Nov 14;56(21):8352-65. doi: 10.1021/jm400704g. Epub 2013 Oct 30. J Med Chem. 2013. PMID: 24098954 Free PMC article.
Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition.
Johnstone TB, Gu Z, Yoshimura RF, Villegier AS, Hogenkamp DJ, Whittemore ER, Huang JC, Tran MB, Belluzzi JD, Yakel JL, Gee KW. Johnstone TB, et al. Among authors: yoshimura rf. J Pharmacol Exp Ther. 2011 Mar;336(3):908-15. doi: 10.1124/jpet.110.176255. Epub 2010 Dec 15. J Pharmacol Exp Ther. 2011. PMID: 21159751 Free PMC article.
14 results