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Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis.
Su M, Zhao W, Jiang H, Zhao Y, Liao Z, Liu Z, Xu M, Jiang S, Wu L, Yang Y, Wang Z, Zeng Z, Fang Y, Tang C, Miller CL, Evans PC, Wang L, Banach M, Jo H, Berk BC, Offermanns S, Huang Y, Ge J, Xu S, Weng J. Su M, et al. Among authors: fang y. Nat Cardiovasc Res. 2025 Jan 10. doi: 10.1038/s44161-024-00591-0. Online ahead of print. Nat Cardiovasc Res. 2025. PMID: 39794479
JAG1-NOTCH4 mechanosensing drives atherosclerosis.
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis SE, Chico TJ, Serbanovic-Canic J, Evans PC. Souilhol C, et al. Among authors: fang y. Sci Adv. 2022 Sep 2;8(35):eabo7958. doi: 10.1126/sciadv.abo7958. Epub 2022 Aug 31. Sci Adv. 2022. PMID: 36044575 Free PMC article.
The guidance receptor plexin D1 is a mechanosensor in endothelial cells.
Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E. Mehta V, et al. Among authors: fang y. Nature. 2020 Feb;578(7794):290-295. doi: 10.1038/s41586-020-1979-4. Epub 2020 Feb 5. Nature. 2020. PMID: 32025034 Free PMC article.
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling AI, Guzy RD, Fang Y, Yang KC. Lee TH, et al. Among authors: fang y. Nat Commun. 2020 Aug 26;11(1):4254. doi: 10.1038/s41467-020-18047-x. Nat Commun. 2020. PMID: 32848143 Free PMC article.
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