Jafar-Nejad P - Search Results

1

Loss of CHOP Prevents Joint Degeneration and Pain in a Mouse Model of Pseudoachondroplasia.

Hecht JT, Veerisetty AC, Hossain MG, Patra D, Carrer M, Chiu F, Relic D, Jafar-Nejad P, Posey KL. Hecht JT, et al. Among authors: jafar nejad p. Int J Mol Sci. 2024 Dec 24;26(1):16. doi: 10.3390/ijms26010016. Int J Mol Sci. 2024. PMID: 39795874 Free PMC article.

2

Molecular Profiling of Mouse Models of Loss or Gain of Function of the KCNT1 (Slack) Potassium Channel and Antisense Oligonucleotide Treatment.

Sun F, Wang H, Wu J, Quraishi IH, Zhang Y, Pedram M, Gao B, Jonas EA, Nguyen V, Wu S, Mabrouk OS, Jafar-Nejad P, Kaczmarek LK. Sun F, et al. Among authors: jafar nejad p. Biomolecules. 2024 Nov 2;14(11):1397. doi: 10.3390/biom14111397. Biomolecules. 2024. PMID: 39595574 Free PMC article.

3

Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels.

Bajikar SS, Sztainberg Y, Trostle AJ, Tirumala HP, Wan YW, Harrop CL, Bengtsson JD, Carvalho CMB, Pehlivan D, Suter B, Neul JL, Liu Z, Jafar-Nejad P, Rigo F, Zoghbi HY. Bajikar SS, et al. Among authors: jafar nejad p. Hum Mol Genet. 2024 Nov 8;33(22):1986-2001. doi: 10.1093/hmg/ddae135. Hum Mol Genet. 2024. PMID: 39277796 Free PMC article.

4

Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice.

Schoch KM, Ezerskiy LA, Morhaus MM, Bannon RN, Sauerbeck AD, Shabsovich M, Jafar-Nejad P, Rigo F, Miller TM. Schoch KM, et al. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2100356118. doi: 10.1073/pnas.2100356118. Proc Natl Acad Sci U S A. 2021. PMID: 34187891 Free PMC article.

5

Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice.

Spiller KJ, Khan T, Dominique MA, Restrepo CR, Cotton-Samuel D, Levitan M, Jafar-Nejad P, Zhang B, Soriano A, Rigo F, Trojanowski JQ, Lee VM. Spiller KJ, et al. Neurobiol Dis. 2019 Apr;124:133-140. doi: 10.1016/j.nbd.2018.11.013. Epub 2018 Nov 17. Neurobiol Dis. 2019. PMID: 30458231 Free PMC article.

6

Antisense oligonucleotide therapy in a humanized mouse model of MECP2 duplication syndrome.

Shao Y, Sztainberg Y, Wang Q, Bajikar SS, Trostle AJ, Wan YW, Jafar-Nejad P, Rigo F, Liu Z, Tang J, Zoghbi HY. Shao Y, et al. Sci Transl Med. 2021 Mar 3;13(583):eaaz7785. doi: 10.1126/scitranslmed.aaz7785. Sci Transl Med. 2021. PMID: 33658357 Free PMC article.

7

Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia.

Smith DM, Niehoff ML, Ling K, Jafar-Nejad P, Rigo F, Farr SA, Wilkinson MF, Nguyen AD. Smith DM, et al. PLoS One. 2023 Mar 9;18(3):e0282822. doi: 10.1371/journal.pone.0282822. eCollection 2023. PLoS One. 2023. PMID: 36893203 Free PMC article.

8

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

Hill SF, Jafar-Nejad P, Rigo F, Meisler MH. Hill SF, et al. Front Neurosci. 2023 Oct 13;17:1282201. doi: 10.3389/fnins.2023.1282201. eCollection 2023. Front Neurosci. 2023. PMID: 37901435 Free PMC article.

9

Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.

Chen CJ, Sgritta M, Mays J, Zhou H, Lucero R, Park J, Wang IC, Park JH, Kaipparettu BA, Stoica L, Jafar-Nejad P, Rigo F, Chin J, Noebels JL, Costa-Mattioli M. Chen CJ, et al. Nat Med. 2019 Nov;25(11):1684-1690. doi: 10.1038/s41591-019-0608-y. Epub 2019 Oct 21. Nat Med. 2019. PMID: 31636454 Free PMC article.

10

ASO silencing of a glycosyltransferase, Poglut1 , improves the liver phenotypes in mouse models of Alagille syndrome.

Niknejad N, Fox D, Burwinkel JL, Zarrin-Khameh N, Cho S, Soriano A, Cast AE, Lopez MF, Huppert KA, Rigo F, Huppert SS, Jafar-Nejad P, Jafar-Nejad H. Niknejad N, et al. Hepatology. 2023 Nov 1;78(5):1337-1351. doi: 10.1097/HEP.0000000000000380. Epub 2023 Apr 7. Hepatology. 2023. PMID: 37021797 Free PMC article.

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