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Key considerations for combination therapy in Alzheimer's clinical trials: Perspectives from an expert advisory board convened by the Alzheimer's drug discovery foundation.
Cummings J, Gold M, Mintun M, Irizarry M, von Eschenbach A, Hendrix S, Berry D, Sampaio C, Sink K, Landen J, Kivipelto M, Grundman M, Arnold SE, Green A, Partrick K, Nisenbaum L, Burstein A, Fillit H. Cummings J, et al. Among authors: irizarry m. J Prev Alzheimers Dis. 2025 Jan;12(1):100001. doi: 10.1016/j.tjpad.2024.100001. Epub 2025 Jan 1. J Prev Alzheimers Dis. 2025. PMID: 39800453 Free article.
Clinical Meaningfulness in Alzheimer's Disease Clinical Trials. A Report from the EU-US CTAD Task Force.
Angioni D, Cummings J, Lansdall CJ, Middleton L, Sampaio C, Gauthier S, Cohen S, Petersen RC, Rentz DM, Wessels AM, Hendrix SB, Jessen F, Carrillo MC, Doody RS, Irizarry M, Andrews JS, Vellas B, Aisen P. Angioni D, et al. Among authors: irizarry m. J Prev Alzheimers Dis. 2024;11(5):1219-1227. doi: 10.14283/jpad.2024.112. J Prev Alzheimers Dis. 2024. PMID: 39350367 Free PMC article.
Benefits and risks of FDA-approved amyloid-targeting antibodies for treatment of early Alzheimer's disease: Navigating clinician-patient engagement.
Rentz DM, Aisen PS, Atri A, Hitchcock J, Irizarry M, Landen J, Matthews BR, Miller DS, Mahinrad S, Napoli S, Okhravi HR, Petersen RC, Siemers ER, Weber CJ, Weisman DC, Carrillo MC. Rentz DM, et al. Among authors: irizarry m. Alzheimers Dement. 2024 Nov;20(11):8162-8171. doi: 10.1002/alz.14199. Epub 2024 Sep 22. Alzheimers Dement. 2024. PMID: 39306695 Free PMC article.
Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study.
McDade E, Cummings JL, Dhadda S, Swanson CJ, Reyderman L, Kanekiyo M, Koyama A, Irizarry M, Kramer LD, Bateman RJ. McDade E, et al. Among authors: irizarry m. Alzheimers Res Ther. 2022 Dec 21;14(1):191. doi: 10.1186/s13195-022-01124-2. Alzheimers Res Ther. 2022. PMID: 36544184 Free PMC article. Clinical Trial.
Harmonizing tau positron emission tomography in Alzheimer's disease: The CenTauR scale and the joint propagation model.
Leuzy A, Raket LL, Villemagne VL, Klein G, Tonietto M, Olafson E, Baker S, Saad ZS, Bullich S, Lopresti B, Bohorquez SS, Boada M, Betthauser TJ, Charil A, Collins EC, Collins JA, Cullen N, Gunn RN, Higuchi M, Hostetler E, Hutchison RM, Iaccarino L, Insel PS, Irizarry MC, Jack CR Jr, Jagust WJ, Johnson KA, Johnson SC, Karten Y, Marquié M, Mathotaarachchi S, Mintun MA, Ossenkoppele R, Pappas I, Petersen RC, Rabinovici GD, Rosa-Neto P, Schwarz CG, Smith R, Stephens AW, Whittington A, Carrillo MC, Pontecorvo MJ, Haeberlein SB, Dunn B, Kolb HC, Sivakumaran S, Rowe CC, Hansson O, Doré V. Leuzy A, et al. Among authors: irizarry mc. Alzheimers Dement. 2024 Sep;20(9):5833-5848. doi: 10.1002/alz.13908. Epub 2024 Jul 23. Alzheimers Dement. 2024. PMID: 39041435 Free PMC article.
Eligibility Rates among Racially and Ethnically Diverse US Participants in Phase 2 and Phase 3 Placebo-Controlled, Double-Blind, Randomized Trials of Lecanemab and Elenbecestat in Early Alzheimer Disease.
Grill JD, Flournoy C, Dhadda S, Ernstrom K, Sperling R, Molina-Henry D, Tranotti K, Harris R, Kanekiyo M, Gee M, Irizarry M, Kramer L, Aisen P, Raman R. Grill JD, et al. Among authors: irizarry m. Ann Neurol. 2024 Feb;95(2):288-298. doi: 10.1002/ana.26819. Epub 2023 Oct 25. Ann Neurol. 2024. PMID: 37830926 Free PMC article.
150 results