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Page 1
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells.
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjørn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE. Hefzi H, et al. Among authors: barron n. Nat Metab. 2025 Jan 14. doi: 10.1038/s42255-024-01193-7. Online ahead of print. Nat Metab. 2025. PMID: 39809975
Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells.
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjorn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE. Hefzi H, et al. Among authors: barron n. bioRxiv [Preprint]. 2024 Aug 6:2024.08.02.606284. doi: 10.1101/2024.08.02.606284. bioRxiv. 2024. Update in: Nat Metab. 2025 Jan 14. doi: 10.1038/s42255-024-01193-7 PMID: 39211256 Free PMC article. Updated. Preprint.
Detection of host cell microprotein impurities in antibody drug products.
Tzani I, Castro-Rivadeneyra M, Kelly P, Strasser L, Zhang L, Clynes M, Karger BL, Barron N, Bones J, Clarke C. Tzani I, et al. Among authors: barron n. Nat Commun. 2024 Oct 4;15(1):8605. doi: 10.1038/s41467-024-51870-0. Nat Commun. 2024. PMID: 39366928 Free PMC article.
A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency.
Guapo F, Donohue N, Strasser L, Boi S, Füssl F, Rainbow-Fletcher A, Getty P, Anderson I, Barron N, Bones J. Guapo F, et al. Among authors: barron n. Int J Mol Sci. 2024 Feb 28;25(5):2785. doi: 10.3390/ijms25052785. Int J Mol Sci. 2024. PMID: 38474031 Free PMC article.
A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody-Drug Conjugates.
Barron N, Dickgiesser S, Fleischer M, Bachmann AN, Klewinghaus D, Hannewald J, Ciesielski E, Kusters I, Hammann T, Krause V, Fuchs SW, Siegmund V, Gross AW, Mueller-Pompalla D, Krah S, Zielonka S, Doerner A. Barron N, et al. Int J Mol Sci. 2024 Feb 8;25(4):2097. doi: 10.3390/ijms25042097. Int J Mol Sci. 2024. PMID: 38396776 Free PMC article.
137 results