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21 results

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Page 1
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells.
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjørn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE. Hefzi H, et al. Nat Metab. 2025 Jan 14. doi: 10.1038/s42255-024-01193-7. Online ahead of print. Nat Metab. 2025. PMID: 39809975
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion.
Gutierrez JM, Feizi A, Li S, Kallehauge TB, Hefzi H, Grav LM, Ley D, Baycin Hizal D, Betenbaugh MJ, Voldborg B, Faustrup Kildegaard H, Min Lee G, Palsson BO, Nielsen J, Lewis NE. Gutierrez JM, et al. Among authors: hefzi h. Nat Commun. 2020 Jan 2;11(1):68. doi: 10.1038/s41467-019-13867-y. Nat Commun. 2020. PMID: 31896772 Free PMC article.
An optimized genome-wide, virus-free CRISPR screen for mammalian cells.
Xiong K, Karottki KJC, Hefzi H, Li S, Grav LM, Li S, Spahn P, Lee JS, Ventina I, Lee GM, Lewis NE, Kildegaard HF, Pedersen LE. Xiong K, et al. Among authors: hefzi h. Cell Rep Methods. 2021 Aug 23;1(4):100062. doi: 10.1016/j.crmeth.2021.100062. Epub 2021 Aug 4. Cell Rep Methods. 2021. PMID: 34935002 Free PMC article.
Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells.
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjorn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE. Hefzi H, et al. bioRxiv [Preprint]. 2024 Aug 6:2024.08.02.606284. doi: 10.1101/2024.08.02.606284. bioRxiv. 2024. Update in: Nat Metab. 2025 Jan 14. doi: 10.1038/s42255-024-01193-7 PMID: 39211256 Free PMC article. Updated. Preprint.
A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.
Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, Wulff T, Arnsdorf J, Li S, Lee JS, Paglia G, Loira N, Spahn PN, Pedersen LE, Gutierrez JM, King ZA, Lund AM, Nagarajan H, Thomas A, Abdel-Haleem AM, Zanghellini J, Kildegaard HF, Voldborg BG, Gerdtzen ZP, Betenbaugh MJ, Palsson BO, Andersen MR, Nielsen LK, Borth N, Lee DY, Lewis NE. Hefzi H, et al. Cell Syst. 2016 Nov 23;3(5):434-443.e8. doi: 10.1016/j.cels.2016.10.020. Cell Syst. 2016. PMID: 27883890 Free PMC article.
Awakening dormant glycosyltransferases in CHO cells with CRISPRa.
Karottki KJC, Hefzi H, Xiong K, Shamie I, Hansen AH, Li S, Pedersen LE, Li S, Lee JS, Lee GM, Kildegaard HF, Lewis NE. Karottki KJC, et al. Among authors: hefzi h. Biotechnol Bioeng. 2020 Feb;117(2):593-598. doi: 10.1002/bit.27199. Epub 2019 Nov 12. Biotechnol Bioeng. 2020. PMID: 31631317 Free PMC article.
21 results