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Page 1
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells.
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjørn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE. Hefzi H, et al. Among authors: jensen kl. Nat Metab. 2025 Jan 14. doi: 10.1038/s42255-024-01193-7. Online ahead of print. Nat Metab. 2025. PMID: 39809975
Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals.
Lennen RM, Lim HG, Jensen K, Mohammed ET, Phaneuf PV, Noh MH, Malla S, Börner RA, Chekina K, Özdemir E, Bonde I, Koza A, Maury J, Pedersen LE, Schöning LY, Sonnenschein N, Palsson BO, Nielsen AT, Sommer MOA, Herrgård MJ, Feist AM. Lennen RM, et al. Metab Eng. 2023 Mar;76:179-192. doi: 10.1016/j.ymben.2023.01.012. Epub 2023 Feb 3. Metab Eng. 2023. PMID: 36738854 Free article.
Peripherally restricted PICK1 inhibitor mPD5 ameliorates pain behaviors in murine inflammatory and neuropathic pain models.
Jensen KL, Christensen NR, Goddard CM, Jager SE, Noes-Holt G, Kanneworff IB, Jakobsen A, Jiménez-Fernández L, Peck EG, Sivertsen L, Comaposada Baro R, Houser GA, Mayer FP, Diaz-delCastillo M, Topp ML, Hopkins C, Thomsen CD, Soltan ABI, Tidemand FG, Arleth L, Heegaard AM, Sørensen AT, Madsen KL. Jensen KL, et al. JCI Insight. 2024 Sep 17;9(20):e170976. doi: 10.1172/jci.insight.170976. JCI Insight. 2024. PMID: 39287978 Free PMC article.
Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells.
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjorn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE. Hefzi H, et al. Among authors: jensen kl. bioRxiv [Preprint]. 2024 Aug 6:2024.08.02.606284. doi: 10.1101/2024.08.02.606284. bioRxiv. 2024. Update in: Nat Metab. 2025 Jan 14. doi: 10.1038/s42255-024-01193-7 PMID: 39211256 Free PMC article. Updated. Preprint.
An atlas of GPCRs in dopamine neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water intake.
Apuschkin M, Burm HB, Schmidt JH, Skov LJ, Andersen RC, Bowin CF, Støier JF, Jensen KL, Posselt LP, Dmytriyeva O, Sørensen AT, Egerod KL, Holst B, Rickhag M, Schwartz TW, Gether U. Apuschkin M, et al. Among authors: jensen kl. Cell Rep. 2024 Jul 23;43(7):114509. doi: 10.1016/j.celrep.2024.114509. Epub 2024 Jul 13. Cell Rep. 2024. PMID: 39003735 Free article.
Venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain conditions.
Bjørn-Yoshimoto WE, Ramiro IBL, Koch TL, Engholm E, Yeung HY, Sørensen KK, Goddard CM, Jensen KL, Smith NA, Martin LF, Smith BJ, Madsen KL, Jensen KJ, Patwardhan A, Safavi-Hemami H. Bjørn-Yoshimoto WE, et al. Among authors: jensen kl. bioRxiv [Preprint]. 2024 Apr 30:2024.04.29.591104. doi: 10.1101/2024.04.29.591104. bioRxiv. 2024. PMID: 38746149 Free PMC article. Preprint.
Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans.
Schäfer A, Gralinski LE, Leist SR, Hampton BK, Mooney MA, Jensen KL, Graham RL, Agnihothram S, Jeng S, Chamberlin S, Bell TA, Scobey DT, Linnertz CL, VanBlargan LA, Thackray LB, Hock P, Miller DR, Shaw GD, Diamond MS, de Villena FPM, McWeeney SK, Heise MT, Menachery VD, Ferris MT, Baric RS. Schäfer A, et al. Among authors: jensen kl. Virus Res. 2024 Jun;344:199357. doi: 10.1016/j.virusres.2024.199357. Epub 2024 Mar 23. Virus Res. 2024. PMID: 38508400 Free PMC article.
120 results