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Page 1
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells.
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjørn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE. Hefzi H, et al. Among authors: karottki kjc. Nat Metab. 2025 Jan 14. doi: 10.1038/s42255-024-01193-7. Online ahead of print. Nat Metab. 2025. PMID: 39809975
Multiplex genome editing eliminates the Warburg Effect without impacting growth rate in mammalian cells.
Hefzi H, Martínez-Monge I, Marin de Mas I, Cowie NL, Toledo AG, Noh SM, Karottki KJC, Decker M, Arnsdorf J, Camacho-Zaragoza JM, Kol S, Schoffelen S, Pristovšek N, Hansen AH, Miguez AA, Bjorn SP, Brøndum KK, Javidi EM, Jensen KL, Stangl L, Kreidl E, Kallehauge TB, Ley D, Ménard P, Petersen HM, Sukhova Z, Bauer A, Casanova E, Barron N, Malmström J, Nielsen LK, Lee GM, Kildegaard HF, Voldborg BG, Lewis NE. Hefzi H, et al. Among authors: karottki kjc. bioRxiv [Preprint]. 2024 Aug 6:2024.08.02.606284. doi: 10.1101/2024.08.02.606284. bioRxiv. 2024. Update in: Nat Metab. 2025 Jan 14. doi: 10.1038/s42255-024-01193-7 PMID: 39211256 Free PMC article. Updated. Preprint.
Erratum: An optimized genome-wide, virus-free CRISPR screen for mammalian cells.
Xiong K, Karottki KJC, Hefzi H, Li S, Grav LM, Li S, Spahn P, Lee JS, Ventina I, Lee GM, Lewis NE, Kildegaard HF, Pedersen LE. Xiong K, et al. Among authors: karottki kjc. Cell Rep Methods. 2021 Nov 22;1(7):100115. doi: 10.1016/j.crmeth.2021.100115. eCollection 2021 Nov 22. Cell Rep Methods. 2021. PMID: 35475003 Free PMC article.
An optimized genome-wide, virus-free CRISPR screen for mammalian cells.
Xiong K, Karottki KJC, Hefzi H, Li S, Grav LM, Li S, Spahn P, Lee JS, Ventina I, Lee GM, Lewis NE, Kildegaard HF, Pedersen LE. Xiong K, et al. Among authors: karottki kjc. Cell Rep Methods. 2021 Aug 23;1(4):100062. doi: 10.1016/j.crmeth.2021.100062. Epub 2021 Aug 4. Cell Rep Methods. 2021. PMID: 34935002 Free PMC article.
A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells.
Shamie I, Duttke SH, Karottki KJC, Han CZ, Hansen AH, Hefzi H, Xiong K, Li S, Roth SJ, Tao J, Lee GM, Glass CK, Kildegaard HF, Benner C, Lewis NE. Shamie I, et al. Among authors: karottki kjc. NAR Genom Bioinform. 2021 Jul 13;3(3):lqab061. doi: 10.1093/nargab/lqab061. eCollection 2021 Sep. NAR Genom Bioinform. 2021. PMID: 34268494 Free PMC article.
Awakening dormant glycosyltransferases in CHO cells with CRISPRa.
Karottki KJC, Hefzi H, Xiong K, Shamie I, Hansen AH, Li S, Pedersen LE, Li S, Lee JS, Lee GM, Kildegaard HF, Lewis NE. Karottki KJC, et al. Biotechnol Bioeng. 2020 Feb;117(2):593-598. doi: 10.1002/bit.27199. Epub 2019 Nov 12. Biotechnol Bioeng. 2020. PMID: 31631317 Free PMC article.