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Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.
Mutlu B, Sharabi K, Sohn JH, Yuan B, Latorre-Muro P, Qin X, Yook JS, Lin H, Yu D, Camporez JPG, Kajimura S, Shulman GI, Hui S, Kamenecka TM, Griffin PR, Puigserver P. Mutlu B, et al. Among authors: sharabi k. Cell Chem Biol. 2025 Jan 14:S2451-9456(25)00005-4. doi: 10.1016/j.chembiol.2025.01.005. Online ahead of print. Cell Chem Biol. 2025. PMID: 39814023 No abstract available.
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.
Mutlu B, Sharabi K, Sohn JH, Yuan B, Latorre-Muro P, Qin X, Yook JS, Lin H, Yu D, Camporez JPG, Kajimura S, Shulman GI, Hui S, Kamenecka TM, Griffin PR, Puigserver P. Mutlu B, et al. Among authors: sharabi k. Cell Chem Biol. 2024 Oct 17;31(10):1772-1786.e5. doi: 10.1016/j.chembiol.2024.09.001. Epub 2024 Sep 27. Cell Chem Biol. 2024. PMID: 39341205
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.
Sohn JH, Mutlu B, Latorre-Muro P, Liang J, Bennett CF, Sharabi K, Kantorovich N, Jedrychowski M, Gygi SP, Banks AS, Puigserver P. Sohn JH, et al. Among authors: sharabi k. Cell Metab. 2023 Aug 8;35(8):1356-1372.e5. doi: 10.1016/j.cmet.2023.06.015. Epub 2023 Jul 19. Cell Metab. 2023. PMID: 37473754 Free PMC article.
Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency.
Luo C, Liang J, Sharabi K, Hatting M, Perry EA, Tavares CDJ, Goyal L, Srivastava A, Bilodeau M, Zhu AX, Sicinski P, Puigserver P. Luo C, et al. Among authors: sharabi k. Cancer Res. 2020 Aug 15;80(16):3215-3221. doi: 10.1158/0008-5472.CAN-20-0106. Epub 2020 Jun 30. Cancer Res. 2020. PMID: 32606000 Free PMC article.
Elevated CO2 regulates the Wnt signaling pathway in mammals, Drosophila melanogaster and Caenorhabditis elegans.
Shigemura M, Lecuona E, Angulo M, Dada LA, Edwards MB, Welch LC, Casalino-Matsuda SM, Sporn PHS, Vadász I, Helenius IT, Nader GA, Gruenbaum Y, Sharabi K, Cummins E, Taylor C, Bharat A, Gottardi CJ, Beitel GJ, Kaminski N, Budinger GRS, Berdnikovs S, Sznajder JI. Shigemura M, et al. Among authors: sharabi k. Sci Rep. 2019 Dec 3;9(1):18251. doi: 10.1038/s41598-019-54683-0. Sci Rep. 2019. PMID: 31796806 Free PMC article.
Insulin regulation of gluconeogenesis.
Hatting M, Tavares CDJ, Sharabi K, Rines AK, Puigserver P. Hatting M, et al. Among authors: sharabi k. Ann N Y Acad Sci. 2018 Jan;1411(1):21-35. doi: 10.1111/nyas.13435. Epub 2017 Sep 3. Ann N Y Acad Sci. 2018. PMID: 28868790 Free PMC article. Review.
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