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A phase 1 study to assess the absolute bioavailability, mass balance, pharmacokinetics, metabolism, and excretion of [14C]-mobocertinib, an oral inhibitor of EGFR exon 20 insertion mutations, in healthy participants.
Hanley MJ, Zhang S, Griffin R, Zhu SX, Fram RJ, Lin J, Venkatakrishnan K, Gupta N. Hanley MJ, et al. Invest New Drugs. 2024 Aug;42(4):343-352. doi: 10.1007/s10637-024-01446-y. Epub 2024 May 24. Invest New Drugs. 2024. PMID: 38789848 Free PMC article. Clinical Trial.
Brigatinib pharmacokinetics in patients with chronic hepatic impairment.
Hanley MJ, Kerstein D, Tugnait M, Narasimhan N, Marbury TC, Venkatakrishnan K, Gupta N. Hanley MJ, et al. Invest New Drugs. 2023 Jun;41(3):402-410. doi: 10.1007/s10637-023-01339-6. Epub 2023 Apr 13. Invest New Drugs. 2023. PMID: 37052729 Free PMC article.
Population pharmacokinetic/pharmacodynamic joint modeling of ixazomib efficacy and safety using data from the pivotal phase III TOURMALINE-MM1 study in multiple myeloma patients.
Srimani JK, Diderichsen PM, Hanley MJ, Venkatakrishnan K, Labotka R, Gupta N. Srimani JK, et al. Among authors: hanley mj. CPT Pharmacometrics Syst Pharmacol. 2022 Aug;11(8):1085-1099. doi: 10.1002/psp4.12815. Epub 2022 Jun 13. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35598166 Free PMC article.
64 results