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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.
Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC. Li M, et al. Among authors: hardie dg. Cell Metab. 2025 Jan 15:S1550-4131(25)00003-8. doi: 10.1016/j.cmet.2025.01.003. Online ahead of print. Cell Metab. 2025. PMID: 39818210 No abstract available.
The pro-drug C13 activates AMPK by two distinct mechanisms.
Freemantle JB, Shah D, Lynch DM, Ciulli A, Hundal HS, Hardie DG. Freemantle JB, et al. Among authors: hardie dg. Biochem J. 2024 Sep 18;481(18):1203-1219. doi: 10.1042/BCJ20240425. Biochem J. 2024. PMID: 39222030 Free PMC article.
CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation.
Lopez-Mejia IC, Lagarrigue S, Giralt A, Martinez-Carreres L, Martín J, Ortega S, Zanou N, Denechaud PD, Castillo-Armengol J, Chavey C, Orpinell M, Delacuisine B, Nasrallah A, Collodet C, Zhang L, Viollet B, Hardie DG, Fajas L. Lopez-Mejia IC, et al. Among authors: hardie dg. Mol Cell. 2024 Jun 20;84(12):2397. doi: 10.1016/j.molcel.2024.05.021. Epub 2024 May 31. Mol Cell. 2024. PMID: 38823385 No abstract available.
Staving off cell death.
Hardie DG. Hardie DG. Science. 2023 Jun 30;380(6652):1322-1323. doi: 10.1126/science.adi6827. Epub 2023 Jun 29. Science. 2023. PMID: 37384699
349 results