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Page 1
Interferon-α promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic β-cells.
Carré A, Samassa F, Zhou Z, Perez-Hernandez J, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, Brandao B, Colli ML, Eizirik DL, Aluri J, Patel D, Göransson M, Burgos Morales O, Anderson A, Landry L, Kobaisi F, Scharfmann R, Marselli L, Marchetti P, You S, Nakayama M, Hadrup SR, Kent SC, Richardson SJ, Ternette N, Mallone R. Carré A, et al. Among authors: scharfmann r. Nat Commun. 2025 Jan 17;16(1):765. doi: 10.1038/s41467-025-55908-9. Nat Commun. 2025. PMID: 39824805
Imaging human pancreatic endocrinogenesis during early prenatal life.
Villalba A, Gitton Y, Aiello V, Toupin M, Mazaud-Guittot S, Chédotal A, Scharfmann R. Villalba A, et al. Among authors: scharfmann r. Diabetes. 2024 Nov 27:db240641. doi: 10.2337/db24-0641. Online ahead of print. Diabetes. 2024. PMID: 39602451
Inceptor binds to and directs insulin towards lysosomal degradation in β cells.
Siehler J, Bilekova S, Chapouton P, Dema A, Albanese P, Tamara S, Jain C, Sterr M, Enos SJ, Chen C, Malhotra C, Villalba A, Schomann L, Bhattacharya S, Feng J, Akgün Canan M, Ribaudo F, Ansarullah, Burtscher I, Ahlbrecht C, Plettenburg O, Kurth T, Scharfmann R, Speier S, Scheltema RA, Lickert H. Siehler J, et al. Among authors: scharfmann r. Nat Metab. 2024 Dec;6(12):2374-2390. doi: 10.1038/s42255-024-01164-y. Epub 2024 Nov 25. Nat Metab. 2024. PMID: 39587340 Free PMC article.
Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function.
Meulebrouck S, Merrheim J, Queniat G, Bourouh C, Derhourhi M, Boissel M, Yi X, Badreddine A, Boutry R, Leloire A, Toussaint B, Amanzougarene S, Vaillant E, Durand E, Loiselle H, Huyvaert M, Dechaume A, Scherrer V, Marchetti P, Balkau B, Charpentier G, Franc S, Marre M, Roussel R, Scharfmann R, Cnop M, Canouil M, Baron M, Froguel P, Bonnefond A. Meulebrouck S, et al. Among authors: scharfmann r. Nat Commun. 2024 Aug 5;15(1):6627. doi: 10.1038/s41467-024-51004-6. Nat Commun. 2024. PMID: 39103322 Free PMC article.
Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes.
Zhu S, Waeckel-Énée E, Oshima M, Moser A, Bessard MA, Gdoura A, Roger K, Mode N, Lipecka J, Yilmaz A, Bertocci B, Diana J, Saintpierre B, Guerrera IC, Scharfmann R, Francesconi S, Mauvais FX, van Endert P. Zhu S, et al. Among authors: scharfmann r. iScience. 2024 May 7;27(6):109929. doi: 10.1016/j.isci.2024.109929. eCollection 2024 Jun 21. iScience. 2024. PMID: 38799566 Free PMC article.
LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells.
Cuozzo F, Viloria K, Shilleh AH, Nasteska D, Frazer-Morris C, Tong J, Jiao Z, Boufersaoui A, Marzullo B, Rosoff DB, Smith HR, Bonner C, Kerr-Conte J, Pattou F, Nano R, Piemonti L, Johnson PRV, Spiers R, Roberts J, Lavery GG, Clark A, Ceresa CDL, Ray DW, Hodson L, Davies AP, Rutter GA, Oshima M, Scharfmann R, Merrins MJ, Akerman I, Tennant DA, Ludwig C, Hodson DJ. Cuozzo F, et al. Among authors: scharfmann r. Cell Rep. 2024 Apr 23;43(4):114047. doi: 10.1016/j.celrep.2024.114047. Epub 2024 Apr 11. Cell Rep. 2024. PMID: 38607916 Free PMC article.
Prospective head-to-head comparison of non-invasive scores for diagnosis of fibrotic MASH in patients with type 2 diabetes.
Castera L, Garteiser P, Laouenan C, Vidal-Trécan T, Vallet-Pichard A, Manchon P, Paradis V, Czernichow S, Roulot D, Larger E, Pol S, Bedossa P, Correas JM, Valla D, Gautier JF, Van Beers BE; QUID NASH investigators. Castera L, et al. J Hepatol. 2024 Aug;81(2):195-206. doi: 10.1016/j.jhep.2024.03.023. Epub 2024 Mar 27. J Hepatol. 2024. PMID: 38548067
Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8+ T cell responses.
Vecchio F, Carré A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S; nPOD-Virus Working Group; You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Flodstrom-Tullberg M, Mallone R. Vecchio F, et al. Among authors: scharfmann r. Sci Adv. 2024 Mar 8;10(10):eadl1122. doi: 10.1126/sciadv.adl1122. Epub 2024 Mar 6. Sci Adv. 2024. PMID: 38446892 Free PMC article.
200 results