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Page 1
Enhancer Dynamics and Spatial Organization Drive Anatomically Restricted Cellular States in the Human Spinal Cord.
Kandror EK, Wang A, Carriere M, Peterson A, Liao W, Tjärnberg A, Fung JH, Mahbubani KT, Loper J, Pangburn W, Xu Y, Saeb-Parsy K, Rabadan R, Maniatis T, Rizvi AH. Kandror EK, et al. Among authors: saeb parsy k. bioRxiv [Preprint]. 2025 Jan 11:2025.01.10.632483. doi: 10.1101/2025.01.10.632483. bioRxiv. 2025. PMID: 39829819 Free PMC article. Preprint.
Prolonged persistence of mutagenic DNA lesions in somatic cells.
Spencer Chapman M, Mitchell E, Yoshida K, Williams N, Fabre MA, Ranzoni AM, Robinson PS, Kregar LD, Wilk M, Boettcher S, Mahbubani K, Saeb Parsy K, Gowers KHC, Janes SM, Ng SWK, Hoare M, Green AR, Vassiliou GS, Cvejic A, Manz MG, Laurenti E, Martincorena I, Stratton MR, Nangalia J, Coorens THH, Campbell PJ. Spencer Chapman M, et al. Among authors: saeb parsy k. Nature. 2025 Jan 15. doi: 10.1038/s41586-024-08423-8. Online ahead of print. Nature. 2025. PMID: 39814886
Single-cell integration reveals metaplasia in inflammatory gut diseases.
Oliver AJ, Huang N, Bartolome-Casado R, Li R, Koplev S, Nilsen HR, Moy M, Cakir B, Polanski K, Gudiño V, Melón-Ardanaz E, Sumanaweera D, Dimitrov D, Milchsack LM, FitzPatrick MEB, Provine NM, Boccacino JM, Dann E, Predeus AV, To K, Prete M, Chapman JA, Masi AC, Stephenson E, Engelbert J, Lobentanzer S, Perera S, Richardson L, Kapuge R, Wilbrey-Clark A, Semprich CI, Ellams S, Tudor C, Joseph P, Garrido-Trigo A, Corraliza AM, Oliver TRW, Hook CE, James KR, Mahbubani KT, Saeb-Parsy K, Zilbauer M, Saez-Rodriguez J, Høivik ML, Bækkevold ES, Stewart CJ, Berrington JE, Meyer KB, Klenerman P, Salas A, Haniffa M, Jahnsen FL, Elmentaite R, Teichmann SA. Oliver AJ, et al. Among authors: saeb parsy k. Nature. 2024 Nov;635(8039):699-707. doi: 10.1038/s41586-024-07571-1. Epub 2024 Nov 20. Nature. 2024. PMID: 39567783 Free PMC article.
Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium.
Herms A, Fernandez-Antoran D, Alcolea MP, Kalogeropoulou A, Banerjee U, Piedrafita G, Abby E, Valverde-Lopez JA, Ferreira IS, Caseda I, Bejar MT, Dentro SC, Vidal-Notari S, Ong SH, Colom B, Murai K, King C, Mahbubani K, Saeb-Parsy K, Lowe AR, Gerstung M, Jones PH. Herms A, et al. Among authors: saeb parsy k. Nat Genet. 2024 Oct;56(10):2158-2173. doi: 10.1038/s41588-024-01875-8. Epub 2024 Sep 23. Nat Genet. 2024. PMID: 39313617 Free PMC article.
An integrated single-cell reference atlas of the human endometrium.
Marečková M, Garcia-Alonso L, Moullet M, Lorenzi V, Petryszak R, Sancho-Serra C, Oszlanczi A, Icoresi Mazzeo C, Wong FCK, Kelava I, Hoffman S, Krassowski M, Garbutt K, Gaitskell K, Yancheva S, Woon EV, Male V, Granne I, Hellner K, Mahbubani KT, Saeb-Parsy K, Lotfollahi M, Prigmore E, Southcombe J, Dragovic RA, Becker CM, Zondervan KT, Vento-Tormo R. Marečková M, et al. Among authors: saeb parsy k. Nat Genet. 2024 Sep;56(9):1925-1937. doi: 10.1038/s41588-024-01873-w. Epub 2024 Aug 28. Nat Genet. 2024. PMID: 39198675 Free PMC article.
FlowAtlas: an interactive tool for high-dimensional immunophenotyping analysis bridging FlowJo with computational tools in Julia.
Coppard V, Szep G, Georgieva Z, Howlett SK, Jarvis LB, Rainbow DB, Suchanek O, Needham EJ, Mousa HS, Menon DK, Feyertag F, Mahbubani KT, Saeb-Parsy K, Jones JL. Coppard V, et al. Among authors: saeb parsy k. Front Immunol. 2024 Jul 17;15:1425488. doi: 10.3389/fimmu.2024.1425488. eCollection 2024. Front Immunol. 2024. PMID: 39086484 Free PMC article.
Acquisition of epithelial plasticity in human chronic liver disease.
Gribben C, Galanakis V, Calderwood A, Williams EC, Chazarra-Gil R, Larraz M, Frau C, Puengel T, Guillot A, Rouhani FJ, Mahbubani K, Godfrey E, Davies SE, Athanasiadis E, Saeb-Parsy K, Tacke F, Allison M, Mohorianu I, Vallier L. Gribben C, et al. Among authors: saeb parsy k. Nature. 2024 Jun;630(8015):166-173. doi: 10.1038/s41586-024-07465-2. Epub 2024 May 22. Nature. 2024. PMID: 38778114 Free PMC article.
Human skeletal muscle aging atlas.
Kedlian VR, Wang Y, Liu T, Chen X, Bolt L, Tudor C, Shen Z, Fasouli ES, Prigmore E, Kleshchevnikov V, Pett JP, Li T, Lawrence JEG, Perera S, Prete M, Huang N, Guo Q, Zeng X, Yang L, Polański K, Chipampe NJ, Dabrowska M, Li X, Bayraktar OA, Patel M, Kumasaka N, Mahbubani KT, Xiang AP, Meyer KB, Saeb-Parsy K, Teichmann SA, Zhang H. Kedlian VR, et al. Among authors: saeb parsy k. Nat Aging. 2024 May;4(5):727-744. doi: 10.1038/s43587-024-00613-3. Epub 2024 Apr 15. Nat Aging. 2024. PMID: 38622407 Free PMC article.
Multi-omics and imaging mass cytometry characterization of human kidneys to identify pathways and phenotypes associated with impaired kidney function.
Asowata EO, Romoli S, Sargeant R, Tan JY, Hoffmann S, Huang MM, Mahbubani KT, Krause FN, Jachimowicz D, Agren R, Koulman A, Jenkins B, Musial B, Griffin JL, Soderberg M, Ling S, Hansen PBL, Saeb-Parsy K, Woollard KJ. Asowata EO, et al. Among authors: saeb parsy k. Kidney Int. 2024 Jul;106(1):85-97. doi: 10.1016/j.kint.2024.01.041. Epub 2024 Feb 29. Kidney Int. 2024. PMID: 38431215 Free article.
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age.
Wells SB, Rainbow DB, Mark M, Szabo PA, Ergen C, Maceiras AR, Caron DP, Rahmani E, Benuck E, Amiri VVP, Chen D, Wagner A, Howlett SK, Jarvis LB, Ellis KL, Kubota M, Matsumoto R, Mahbubani K, Saeb-Parsy K, Dominguez-Conde C, Richardson L, Xu C, Li S, Mamanova L, Bolt L, Wilk A, Teichmann SA, Farber DL, Sims PA, Jones JL, Yosef N. Wells SB, et al. Among authors: saeb parsy k. bioRxiv [Preprint]. 2024 Jan 4:2024.01.03.573877. doi: 10.1101/2024.01.03.573877. bioRxiv. 2024. PMID: 38260588 Free PMC article. Preprint.
160 results