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First-in-Human clinical trial of a small molecule EBNA1 inhibitor, VK-2019, in patients with Epstein-Barr positive nasopharyngeal cancer, with pharmacokinetic and pharmacodynamic studies.
Colevas AD, Talebi Z, Winters E, Even C, Lee VH, Gillison ML, Khan SA, Lu R, Pinsky BA, Soldan SS, Vladmirova O, Lieberman PM, Messick TE. Colevas AD, et al. Among authors: messick te. Clin Cancer Res. 2025 Jan 20. doi: 10.1158/1078-0432.CCR-24-2814. Online ahead of print. Clin Cancer Res. 2025. PMID: 39831818
Design of novel and highly selective SARS-CoV-2 main protease inhibitors.
Poli ANR, Tietjen I, Nandwana NK, Cassel J, Messick TE, Register ET, Keeney F, Rajaiah R, Verma AK, Pandey K, Acharya A, Byrareddy SN, Montaner LJ, Salvino JM. Poli ANR, et al. Among authors: messick te. Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0056224. doi: 10.1128/aac.00562-24. Epub 2024 Sep 3. Antimicrob Agents Chemother. 2024. PMID: 39225484 Free PMC article.
Metabolomic Analysis and Antiviral Screening of a Marine Algae Library Yield Jobosic Acid (2,5-Dimethyltetradecanoic Acid) as a Selective Inhibitor of SARS-CoV-2.
Matos-Hernández ML, Samples R, Dyer G, Casimir Montán VM, Morales-Colón CA, Salvino JM, Montaner LJ, Cassel JA, Messick TE, Tietjen I, Caro-Diaz EJE. Matos-Hernández ML, et al. Among authors: messick te. J Nat Prod. 2024 Jun 28;87(6):1513-1520. doi: 10.1021/acs.jnatprod.3c01071. Epub 2024 May 23. J Nat Prod. 2024. PMID: 38781491
EBNA1 Inhibitors Block Proliferation of Spontaneous Lymphoblastoid Cell Lines From Patients With Multiple Sclerosis and Healthy Controls.
Monaco MCG, Soldan SS, Su C, Clauze A, Cooper JF, Patel RJ, Lu F, Hughes RJ, Messick TE, Andrada FC, Ohayon J, Lieberman PM, Jacobson S. Monaco MCG, et al. Among authors: messick te. Neurol Neuroimmunol Neuroinflamm. 2023 Aug 10;10(5):e200149. doi: 10.1212/NXI.0000000000200149. Print 2023 Sep. Neurol Neuroimmunol Neuroinflamm. 2023. PMID: 37562974 Free PMC article.
Therapeutic approaches to Epstein-Barr virus cancers.
Soldan SS, Messick TE, Lieberman PM. Soldan SS, et al. Among authors: messick te. Curr Opin Virol. 2022 Oct;56:101260. doi: 10.1016/j.coviro.2022.101260. Epub 2022 Sep 27. Curr Opin Virol. 2022. PMID: 36174496 Free PMC article. Review.
The Natural Stilbenoid (-)-Hopeaphenol Inhibits Cellular Entry of SARS-CoV-2 USA-WA1/2020, B.1.1.7, and B.1.351 Variants.
Tietjen I, Cassel J, Register ET, Zhou XY, Messick TE, Keeney F, Lu LD, Beattie KD, Rali T, Tebas P, Ertl HCJ, Salvino JM, Davis RA, Montaner LJ. Tietjen I, et al. Among authors: messick te. Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0077221. doi: 10.1128/AAC.00772-21. Epub 2021 Sep 20. Antimicrob Agents Chemother. 2021. PMID: 34543092 Free PMC article.
Epigenetic Plasticity Enables CNS-Trafficking of EBV-infected B Lymphocytes.
Soldan SS, Su C, Lamontagne RJ, Grams N, Lu F, Zhang Y, Gesualdi JD, Frase DM, Tolvinski LE, Martin K, Messick TE, Fingerut JT, Koltsova E, Kossenkov A, Lieberman PM. Soldan SS, et al. Among authors: messick te. PLoS Pathog. 2021 Jun 9;17(6):e1009618. doi: 10.1371/journal.ppat.1009618. eCollection 2021 Jun. PLoS Pathog. 2021. PMID: 34106998 Free PMC article.
29 results