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Cell-type-resolved chromatin accessibility in the human intestine identifies complex regulatory programs and clarifies genetic associations in Crohn's disease.
Zhao Y, Zhou R, Mu Z, Carbonetto P, Zhong X, Xie B, Luo K, Cham CM, Koval J, He X, Dahl AW, Liu X, Chang EB, Basu A, Pott S. Zhao Y, et al. Among authors: cham cm. medRxiv [Preprint]. 2024 Dec 11:2024.12.10.24318718. doi: 10.1101/2024.12.10.24318718. medRxiv. 2024. PMID: 39711713 Free PMC article. Preprint.
Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patients.
Zhao Y, Zhou R, Xie B, Liu CY, Kalski M, Cham CM, Jiang Z, Koval J, Weber CR, Rubin DT, Sogin M, Crosson S, Chen M, Huang J, Fiebig A, Dalal S, Chang EB, Basu A, Pott S. Zhao Y, et al. Among authors: cham cm. medRxiv [Preprint]. 2025 Jan 9:2023.11.11.23298309. doi: 10.1101/2023.11.11.23298309. medRxiv. 2025. PMID: 38014192 Free PMC article. Preprint.
Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism.
Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB. Pierre JF, et al. Among authors: cham cm. Science. 2023 Aug 4;381(6657):502-508. doi: 10.1126/science.abq3178. Epub 2023 Aug 3. Science. 2023. PMID: 37535745 Free PMC article.
HMGB1 acts as an agent of host defense at the gut mucosal barrier.
Overstreet AC, Anderson B, Burge M, Zhu X, Tao Y, Cham CM, Michaud B, Horam S, Sangwan N, Dwidar M, Liu X, Santos A, Finney C, Dai Z, Leone VA, Messer JS. Overstreet AC, et al. Among authors: cham cm. bioRxiv [Preprint]. 2023 May 30:2023.05.30.542477. doi: 10.1101/2023.05.30.542477. bioRxiv. 2023. PMID: 37398239 Free PMC article. Preprint.
High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction.
Frazier K, Kambal A, Zale EA, Pierre JF, Hubert N, Miyoshi S, Miyoshi J, Ringus DL, Harris D, Yang K, Carroll K, Hermanson JB, Chlystek JS, Overmyer KA, Cham CM, Musch MW, Coon JJ, Chang EB, Leone VA. Frazier K, et al. Among authors: cham cm. Cell Host Microbe. 2022 Jun 8;30(6):809-823.e6. doi: 10.1016/j.chom.2022.03.030. Epub 2022 Apr 18. Cell Host Microbe. 2022. PMID: 35439436 Free PMC article.
29 results