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Page 1
FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells.
Araújo JL, Wagenblast E, Voisin V, McLeod J, Gan OI, Bansal S, Jin L, Mitchell A, Gratton B, Cutting SK, Arruda A, Doedens M, Travas A, Kim DDH, Capo-Chichi JM, Abelson S PhD, Minden MD, Wang JC, Sobrinho-Simões MA, Pinto-do-Ó P, Lechman ER, Dick JE. Araújo JL, et al. Among authors: wagenblast e. Blood. 2025 Jan 22:blood.2024025886. doi: 10.1182/blood.2024025886. Online ahead of print. Blood. 2025. PMID: 39841016
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer.
Belabed M, Park MD, Blouin CM, Balan S, Moon CY, Freed G, Quijada-Álamo M, Peros A, Mattiuz R, Reid AM, Yatim N, Boumelha J, Azimi CS, LaMarche NM, Troncoso L, Amabile A, Le Berichel J, Chen ST, Wilk CM, Brown BD, Radford KJ, Ghosh S, Rothlin CV, Yvan-Charvet L, Marron TU, Puleston DJ, Wagenblast E, Bhardwaj N, Lamaze C, Merad M. Belabed M, et al. Among authors: wagenblast e. Nat Immunol. 2025 Jan 21. doi: 10.1038/s41590-024-02065-8. Online ahead of print. Nat Immunol. 2025. PMID: 39838105
An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup.
Gower M, Li X, Aguilar-Navarro AG, Lin B, Fernandez M, Edun G, Nader M, Rondeau V, Arruda A, Tierens A, Eames Seffernick A, Pölönen P, Durocher J, Wagenblast E, Yang L, Lee HS, Mullighan CG, Teachey D, Rashkovan M, Tremblay CS, Herranz D, Itkin T, Loghavi S, Dick JE, Schwartz G, Perusini MA, Sibai H, Hitzler J, Gruber TA, Minden M, Jones CL, Dolgalev I, Jahangiri S, Tikhonova AN. Gower M, et al. Among authors: wagenblast e. Sci Transl Med. 2025 Jan;17(779):eadr2012. doi: 10.1126/scitranslmed.adr2012. Epub 2025 Jan 1. Sci Transl Med. 2025. PMID: 39742502
RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax.
Sango J, Carcamo S, Sirenko M, Maiti A, Mansour H, Ulukaya G, Tomalin LE, Cruz-Rodriguez N, Wang T, Olszewska M, Olivier E, Jaud M, Nadorp B, Kroger B, Hu F, Silverman L, Chung SS, Wagenblast E, Chaligne R, Eisfeld AK, Demircioglu D, Landau DA, Lito P, Papaemmanuil E, DiNardo CD, Hasson D, Konopleva M, Papapetrou EP. Sango J, et al. Among authors: wagenblast e. Nature. 2024 Dec;636(8041):241-250. doi: 10.1038/s41586-024-08137-x. Epub 2024 Oct 30. Nature. 2024. PMID: 39478230 Free PMC article.
Down syndrome and leukemia: from basic mechanisms to clinical advances.
Baruchel A, Bourquin JP, Crispino J, Cuartero S, Hasle H, Hitzler J, Klusmann JH, Izraeli S, Lane AA, Malinge S, Rabin KR, Roberts I, Ryeom S, Tasian SK, Wagenblast E. Baruchel A, et al. Among authors: wagenblast e. Haematologica. 2023 Oct 1;108(10):2570-2581. doi: 10.3324/haematol.2023.283225. Haematologica. 2023. PMID: 37439336 Free PMC article. Review.
A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome.
Boutzen H, Madani Tonekaboni SA, Chan-Seng-Yue M, Murison A, Takayama N, Mbong N, Wagenblast E, Orouji E, Arruda A, Mitchell A, Notta F, Minden MD, Lupien M, Kaufmann KB, Dick JE. Boutzen H, et al. Among authors: wagenblast e. Leukemia. 2022 Nov;36(11):2690-2704. doi: 10.1038/s41375-022-01697-9. Epub 2022 Sep 21. Leukemia. 2022. PMID: 36131042 Free PMC article.
25 results