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Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion.
Zotta A, Toller-Kawahisa J, Palsson-McDermott EM, O'Carroll SM, Henry ÓC, Day EA, McGettrick AF, Ward RW, Ryan DG, Watson MA, Brand MD, Runtsch MC, Maitz K, Lueger A, Kargl J, Miljkovic JL, Lavelle EC, O'Neill LAJ. Zotta A, et al. Among authors: brand md. Sci Adv. 2025 Jan 24;11(4):eadq7307. doi: 10.1126/sciadv.adq7307. Epub 2025 Jan 22. Sci Adv. 2025. PMID: 39841829 Free article.
Hypoxia decreases mitochondrial ROS production in cells.
Sen B, Benoit B, Brand MD. Sen B, et al. Among authors: brand md. Free Radic Biol Med. 2024 Nov 1;224:1-8. doi: 10.1016/j.freeradbiomed.2024.08.016. Epub 2024 Aug 13. Free Radic Biol Med. 2024. PMID: 39147069 Free article.
Suppression of superoxide/hydrogen peroxide production at mitochondrial site IQ decreases fat accumulation, improves glucose tolerance and normalizes fasting insulin concentration in mice fed a high-fat diet.
Watson MA, Brar H, Gibbs ET 2nd, Wong HS, Dighe PA, McKibben B, Riedmaier S, Siu A, Polakowski JS, Segreti JA, Liu X, Chung S, Pliushchev YM, Gesmundo N, Wang Z, Vortherms TA, Brand MD. Watson MA, et al. Among authors: brand md. Free Radic Biol Med. 2023 Aug 1;204:276-286. doi: 10.1016/j.freeradbiomed.2023.05.022. Epub 2023 May 20. Free Radic Biol Med. 2023. PMID: 37217089 Free article.
S3QELs protect against diet-induced intestinal barrier dysfunction.
Watson MA, Pattavina B, Hilsabeck TAU, Lopez-Dominguez J, Kapahi P, Brand MD. Watson MA, et al. Among authors: brand md. Aging Cell. 2021 Oct;20(10):e13476. doi: 10.1111/acel.13476. Epub 2021 Sep 14. Aging Cell. 2021. PMID: 34521156 Free PMC article.
Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice.
Wong HS, Mezera V, Dighe P, Melov S, Gerencser AA, Sweis RF, Pliushchev M, Wang Z, Esbenshade T, McKibben B, Riedmaier S, Brand MD. Wong HS, et al. Among authors: brand md. Free Radic Biol Med. 2021 Feb 20;164:223-232. doi: 10.1016/j.freeradbiomed.2020.12.447. Epub 2021 Jan 6. Free Radic Biol Med. 2021. PMID: 33421588 Free article.
330 results