Shymko RM - Search Results

1

Mechanism of insulin and IGF-I receptor activation and signal transduction specificity. Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling.

De Meyts P, Ursø B, Christoffersen CT, Shymko RM. De Meyts P, et al. Among authors: shymko rm. Ann N Y Acad Sci. 1995 Sep 7;766:388-401. doi: 10.1111/j.1749-6632.1995.tb26688.x. Ann N Y Acad Sci. 1995. PMID: 7486684 Review. No abstract available.

2

Role of the time factor in signaling specificity: application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases.

De Meyts P, Christoffersen CT, Ursø B, Wallach B, Grønskov K, Yakushiji F, Shymko RM. De Meyts P, et al. Among authors: shymko rm. Metabolism. 1995 Oct;44(10 Suppl 4):2-11. doi: 10.1016/0026-0495(95)90214-7. Metabolism. 1995. PMID: 7476307 Review.

3

The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction.

De Meyts P, Wallach B, Christoffersen CT, Ursø B, Grønskov K, Latus LJ, Yakushiji F, Ilondo MM, Shymko RM. De Meyts P, et al. Among authors: shymko rm. Horm Res. 1994;42(4-5):152-69. doi: 10.1159/000184188. Horm Res. 1994. PMID: 7868068 Review.

4

Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor.

Christoffersen CT, Bornfeldt KE, Rotella CM, Gonzales N, Vissing H, Shymko RM, ten Hoeve J, Groffen J, Heisterkamp N, De Meyts P. Christoffersen CT, et al. Among authors: shymko rm. Endocrinology. 1994 Jul;135(1):472-5. doi: 10.1210/endo.135.1.8013387. Endocrinology. 1994. PMID: 8013387

5

Mutation of arginine 86 to proline in the insulin receptor alpha subunit causes lack of transport of the receptor to the plasma membrane, loss of binding affinity and a constitutively activated tyrosine kinase in transfected cells.

Grønskov K, Vissing H, Shymko RM, Tornqvist H, De Meyts P. Grønskov K, et al. Among authors: shymko rm. Biochem Biophys Res Commun. 1993 Apr 30;192(2):905-11. doi: 10.1006/bbrc.1993.1501. Biochem Biophys Res Commun. 1993. PMID: 8484793

6

Biosensor measurement of the binding of insulin-like growth factors I and II and their analogues to the insulin-like growth factor-binding protein-3.

Heding A, Gill R, Ogawa Y, De Meyts P, Shymko RM. Heding A, et al. Among authors: shymko rm. J Biol Chem. 1996 Jun 14;271(24):13948-52. doi: 10.1074/jbc.271.24.13948. J Biol Chem. 1996. PMID: 8662901 Free article.

7

Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways.

Shymko RM, De Meyts P, Thomas R. Shymko RM, et al. Biochem J. 1997 Sep 1;326 ( Pt 2)(Pt 2):463-9. doi: 10.1042/bj3260463. Biochem J. 1997. PMID: 9291119 Free PMC article. Review.

8

Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding.

Shymko RM, Dumont E, De Meyts P, Dumont JE. Shymko RM, et al. Biochem J. 1999 May 1;339 ( Pt 3)(Pt 3):675-83. Biochem J. 1999. PMID: 10215607 Free PMC article.

9

Timing-dependent modulation of insulin mitogenic versus metabolic signalling.

De Meyts P, Shymko RM. De Meyts P, et al. Among authors: shymko rm. Novartis Found Symp. 2000;227:46-57; discussion 57-60. doi: 10.1002/0470870796.ch4. Novartis Found Symp. 2000. PMID: 10752064 Review.

10

Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes.

Ilondo MM, Damholt AB, Cunningham BA, Wells JA, De Meyts P, Shymko RM. Ilondo MM, et al. Among authors: shymko rm. Endocrinology. 1994 Jun;134(6):2397-403. doi: 10.1210/endo.134.6.8194466. Endocrinology. 1994. PMID: 8194466

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